97150-65-7

Basic information

• Product Name: 4-amino-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)pyridazinone
• Synonyms: 4-amino-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)pyridazinone
• CAS NO: 97150-65-7
• Molecular Weight: 253.263
• Mol File: 97150-65-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-amino-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)pyridazinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)pyridazinone(97150-65-7)
• EPA Substance Registry System: 4-amino-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)pyridazinone(97150-65-7)

Safety Data

• Hazardous Substances Data: 97150-65-7(Hazardous Substances Data)

Upstream product

• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 
• 10041-06-2 4'-(imidazol-1-yl)acetophenone 
• 97150-79-3 hydroxy<2-<4-(1H-imidazol-1-yl)phenyl>-2-oxoethyl>propanedioic acid diethyl ester 
• 84243-57-2 4-(1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid 
• 84243-59-4 6-<4-(1H-imidazole-1-yl)phenyl>-3(2H)-pyridazinone 
• 97150-66-8 2,3-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3-oxo-4-pyridazinecarboxylic acid hydrazine 
• 84243-58-3 imazodan 

Relevant articles and documents

Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones

Substituted 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinone compounds and 6-(substituted)phenyl-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents. Said compounds cause a significant increase in myocardial contractility in the dog. Said compounds also cause a decrease in blood pressure in the spontaneously hypertensive rat. Said compounds are produced by reacting substituted γ-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones which are dehydrogenated to 6-(substituted)phenyl-3(2H)-pyridazinones. Both the intermediate 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones and the 6-(substituted)phenyl-3(2H)-pyridazinones are useful as cardiotonic and antihypertensive agents.

Cardiotonic Agents. 2. Synthesis and Structure-Activity Relationships of 4,5-Dihydro-6--3(2H)-pyridazinones: A New Class of Positive Inotropic Agents

A series of 4,5-dihydro-6--3(2H)-pyridazinones and related compounds were synthesized and evaluated for positive inotropic activity.Most members of this series produced dose-related increases in myocardial contractility that we