4-(3-Trifluoromethyl-4H-thiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide

Base Information

Chemical Name:4-(3-Trifluoromethyl-4H-thiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide
CAS No.:178975-20-7
Molecular Formula:C₁₇H₁₂F₃N₃O₂S₂
Molecular Weight:411.428
Hs Code.:
Pharos Ligand ID:1JNCBV6LF4TM
ChEMBL ID:CHEMBL273420
Mol file:178975-20-7.mol

Synonyms:178975-20-7;M5;CHEMBL273420;4-[3-(trifluoromethyl)-4H-thiochromeno[4,3-c]pyrazol-1-yl]benzenesulfonamide;4-(3-Trifluoromethyl-4H-thiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide;D0LJ7R;SCHEMBL8933820;BDBM50288327;AB44454;M5, Vascular Laboratory/Thrombolytic Science;Fibrinolytic agent, Vascular Laboratory/Thrombolytic Sciences

Suppliers and Price of 4-(3-Trifluoromethyl-4H-thiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-[3-(TRIFLUOROMETHYL)[1]-BENZOTHIOPYRANO-[4,3-C]PYRAZOL-1(4H)-YL]-BENZENESULFONAMIDE 95.00%
5MG
$ 505.52

Total 1 raw suppliers

Chemical Property of 4-(3-Trifluoromethyl-4H-thiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide

Chemical Property:

PSA：111.66000
LogP:5.59230
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:411.03230347
Heavy Atom Count:27
Complexity:647

Purity/Quality:

95% ^*data from raw suppliers

4-[3-(TRIFLUOROMETHYL)[1]-BENZOTHIOPYRANO-[4,3-C]PYRAZOL-1(4H)-YL]-BENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=C(C3=CC=CC=C3S1)N(N=C2C(F)(F)F)C4=CC=C(C=C4)S(=O)(=O)N
Recent ClinicalTrials:Research Into the Effect of a Clot-dissolving Agent and Its Inhibitor

Technology Process of 4-(3-Trifluoromethyl-4H-thiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide

There total 3 articles about 4-(3-Trifluoromethyl-4H-thiochromeno[4,3-c]pyrazol-1-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 288-13-1
NH-pyrazole

: 178975-20-7
4-[1,4-dihydro-3-(trifluoromethyl)-[1]benzothiopyrano[4,3-c]pyrazol-1-yl]benzenesulfonamide

Guidance literature:

Reference yield:

: 3528-17-4
2,3-dihydro-4H-[1]benzothiopyran-4-one

: 178975-20-7
4-[1,4-dihydro-3-(trifluoromethyl)-[1]benzothiopyrano[4,3-c]pyrazol-1-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOMe / diethyl ether; methanol / 16 h

2: ethanol / Heating

With sodium methylate; In methanol; diethyl ether; ethanol;
DOI:10.1016/S0960-894X(96)00530-6