5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-<<3-methyl-4-<<(methylamino)carbonyl>amino>phenyl>methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid

Base Information

Chemical Name:5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-<<3-methyl-4-<<(methylamino)carbonyl>amino>phenyl>methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid
CAS No.:114785-87-4
Molecular Formula:C₃₁H₃₁N₅O₄
Molecular Weight:537.618
Hs Code.:

Synonyms:5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-<<3-methyl-4-<<(methylamino)carbonyl>amino>phenyl>methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid

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Chemical Property of 5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-<<3-methyl-4-<<(methylamino)carbonyl>amino>phenyl>methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid

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Technology Process of 5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-<<3-methyl-4-<<(methylamino)carbonyl>amino>phenyl>methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid

There total 9 articles about 5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-<<3-methyl-4-<<(methylamino)carbonyl>amino>phenyl>methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-<<3-methyl-4-<<(methylamino)carbonyl>amino>phenyl>methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid methyl ester

: 114785-87-4
5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-<<3-methyl-4-<<(methylamino)carbonyl>amino>phenyl>methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; for 2h; Ambient temperature;
DOI:10.1021/jm00115a014

Reference yield:

: 80866-75-7
3-methyl-4-nitrobenzyl alcohol

: 114785-87-4
5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-<<3-methyl-4-<<(methylamino)carbonyl>amino>phenyl>methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: (iPr)2NEt / CH₂Cl₂ / 0.5 h / -75 °C

2: 1.) CH₂Cl₂, from -75 deg C to RT, 8 h, 2.) CH₂Cl₂, pH 7, 1.5 h

3: 100 percent / 6 N HCl / methanol / 1.5 h / Heating

4: 83 percent / H₂O / 1.) RT, 30 min, 2.) reflux, 90 min

5: 83.3 percent / HCl(g) / methanol / 24 h / Heating

6: 79 percent / dicyclohexylcarbodiimide (DCC), hydroxybenztriazole (HOBT*H₂O) / acetonitrile / 48 h / Ambient temperature

7: 100 percent / H₂ / Raney nickel / tetrahydrofuran; methanol / 6 h / 2585.7 Torr / Ambient temperature

8: 99.4 percent / CH₂Cl₂ / 30 h / 23 °C

9: 78 percent / 1 N NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; nickel; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00115a014

Reference yield:

: Trifluoro-methanesulfonic acid 3-methyl-4-nitro-benzyl ester

: 114785-87-4
5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-<<3-methyl-4-<<(methylamino)carbonyl>amino>phenyl>methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) CH₂Cl₂, from -75 deg C to RT, 8 h, 2.) CH₂Cl₂, pH 7, 1.5 h

2: 100 percent / 6 N HCl / methanol / 1.5 h / Heating

3: 83 percent / H₂O / 1.) RT, 30 min, 2.) reflux, 90 min

4: 83.3 percent / HCl(g) / methanol / 24 h / Heating

5: 79 percent / dicyclohexylcarbodiimide (DCC), hydroxybenztriazole (HOBT*H₂O) / acetonitrile / 48 h / Ambient temperature

6: 100 percent / H₂ / Raney nickel / tetrahydrofuran; methanol / 6 h / 2585.7 Torr / Ambient temperature

7: 99.4 percent / CH₂Cl₂ / 30 h / 23 °C

8: 78 percent / 1 N NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; nickel; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00115a014