80866-75-7

Basic information

• Product Name: 3-METHYL-4-NITROBENZYL ALCOHOL
• Synonyms: 3-METHYL-4-NITROBENZYL ALCOHOL;3-Methyl-4-Nitrobenzylalcohol98%;3-Methyl-4-Nitrobenzylalcohol 98%;(3-Methyl-4-nitrophenyl)Methanol
• CAS NO: 80866-75-7
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• EINECS: 279-578-3
• Product Categories: Alcohols;C7 to C8;Oxygen Compounds
• Mol File: 80866-75-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 57-58 °C(lit.)
• Boiling Point: 295.73°C (rough estimate)
• Flash Point: 145.2 °C
• Appearance: yellow-orange/powder
• Density: 1.2917 (rough estimate)
• Vapor Pressure: 0.000114mmHg at 25°C
• Refractive Index: 1.5570 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 13.62±0.10(Predicted)
• BRN: 2363298
• CAS DataBase Reference: 3-METHYL-4-NITROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-4-NITROBENZYL ALCOHOL(80866-75-7)
• EPA Substance Registry System: 3-METHYL-4-NITROBENZYL ALCOHOL(80866-75-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 80866-75-7(Hazardous Substances Data)

Usage

Uses

3-Methyl-4-nitrobenzyl alcohol was used as starting reagent in the synthesis of 3-methyl-4-iodophenylalanine.

InChI:InChI=1/C8H9NO3/c1-6-4-7(5-10)2-3-8(6)9(11)12/h2-4,10H,5H2,1H3

Upstream product

• 18515-67-8 3-methyl-4-nitro-benzaldehyde 
• 89-87-2 2,4-dimethylnitrobenzene 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 

Downstream Products

• 18515-14-5 4-(chloromethyl)-2-methyl-1-nitro-benzene 
• 141281-38-1 4-(bromomethyl)-2-methyl-1-nitrobenzene 
• 88990-57-2 4-(Hydroxymethyl)-2-methylaniline 
• 946856-95-7 2-(3-methyl-4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione 
• 124597-33-7 (S)-5-diphenylacetyl-1-(3-methyl-4-nitrophenyl) methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid 
• 383666-84-0 ethyl (E)-3-(3-methyl-4-nitrophenyl)acrylate 
• 24078-21-5 methyl 3-methyl-4-nitrobenzoate 
• 343851-08-1 N-(benzyloxycarbonyl)-4-(1,3,6-trimethyl-2,4-dioxo-5-pyrimidinyl)-3-methyl-L-phenylalanine methyl ester 
• 343851-02-5 N-(benzyloxycarbonyl)-4-(1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)-3-methyl-L-phenylalanine methyl ester 
• 721881-92-1 C₁₉H₂₂N₂O₄ 
• 343851-01-4 N-(benzyloxycarbonyl)-4-iodo-3-methyl-L-phenylalanine methyl ester 

Relevant articles and documents

Metal–Organic Framework-Encapsulated CoCu Nanoparticles for the Selective Transfer Hydrogenation of Nitrobenzaldehydes: Engineering Active Armor by the Half-Way Injection Method

A novel armor-type composite of metal–organic framework (MOF)-encapsulated CoCu nanoparticles with a Fe3O4 core (Fe3O4@SiO2-NH2-CoCu@UiO-66) has been designed and synthesized by the half-way injection method, which successfully serves as an efficient and recyclable catalyst for the selective transfer hydrogenation. In this half-way injection approach, the pre-synthetic Fe3O4@SiO2-NH2-CoCu was injected into the UiO-66 precursor solution halfway through the MOF budding period. The formed MOF armor could play a role of providing significant additional catalytic sites besides CoCu nanoparticles, protecting CoCu nanoparticles, and improving the catalyst stability, thus facilitating the selective transfer hydrogenation of nitrobenzaldehydes into corresponding nitrobenzyl alcohols in high selectivity (99 %) and conversion (99 %) rather than nitro group reduction products. Notably, this method achieves the precise assembly of a MOF-encapsulated composite, and the ingenious combination of MOF and nanoparticles exhibits excellent catalytic performance in the selective hydrogen transfer reaction, implementing a “1+1>2” strategy in catalysis.

Combined production method for substituted benzaldehyde, substituted benzyl alcohol and substituted benzoic acid

The invention discloses a combined production method for substituted benzaldehyde, substituted benzyl alcohol and substituted benzoic acid. The method comprises the following steps: (1) oxidation: a step of continuously introducing substituted toluene, a catalyst and oxygen-contained gas into an oxidation reactor and carrying out reaction so as to obtain oxidation reaction liquid; (2) hydrolyzation: a step of allowing the oxidation reaction liquid to continuously enter a hydrolysis reactor, and continuously adding water into the hydrolysis reactor and carrying out reaction so as to obtain a hydrolysis reaction mixture; (3) liquid-liquid layering: a step of layering the hydrolysis reaction mixture so as to obtain an oil phase and an aqueous phase; and (4) separation of products: a step of subjecting the oil phase to distillation so as to respectively obtain incompletely-reacted substituted toluene, substituted benzyl alcohol and substituted benzaldehyde, and subjecting the aqueous phase to cooling, crystallizing and filtering so as to obtain filtrate and substituted benzoic acid. The combined production method provided by the invention has the advantages of high raw material conversion rate, few by-products, good selectivity of target products, greenness and environmental protection.

KINASE INHIBITORS

The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.