2-(3,5-Dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol

Base Information

• Chemical Name: 2-(3,5-Dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol
• CAS No.: 120116-27-0
• Molecular Formula: C₂₀H₂₆O₅
• Molecular Weight: 346.423
• Mol file: 120116-27-0.mol

Synonyms:2-(3,5-Dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol

Chemical Property of 2-(3,5-Dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-Dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol

There total 3 articles about 2-(3,5-Dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-(3,5-dimethoxyphenyl)-2-bromopropane (120078-05-9) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 2-(3,5-Dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol (120116-27-0)

Guidance literature:

With lithium; In tetrahydrofuran; at -20 ℃; Barbier reaction conditions;

DOI:10.1016/S0040-4039(01)93800-6

Reference yield:

3,5-dimethoxy-α,α-dimethyl benzyl alcohol (39507-96-5) → 2-(3,5-Dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol (120116-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / HBr, MgSO₄ / CH₂Cl₂ / 0 °C

2: 65 percent / Li (dispersion) / tetrahydrofuran / -20 °C / Barbier reaction conditions

With hydrogen bromide; lithium; magnesium sulfate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(01)93800-6

Reference yield:

methyl 3,5-dimethoxybenzoate (2150-37-0) → 2-(3,5-Dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol (120116-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / diethyl ether / Ambient temperature

2: 96 percent / HBr, MgSO₄ / CH₂Cl₂ / 0 °C

3: 65 percent / Li (dispersion) / tetrahydrofuran / -20 °C / Barbier reaction conditions

With hydrogen bromide; lithium; magnesium sulfate; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/S0040-4039(01)93800-6

upstream raw materials:

2-(3,5-dimethoxyphenyl)-2-bromopropane

3,4-dimethoxy-benzaldehyde

3,5-dimethoxy-α,α-dimethyl benzyl alcohol

methyl 3,5-dimethoxybenzoate