39507-96-5

Basic information

• Product Name: 2-(3,5-Dimethoxyphenyl)propan-2-ol
• Synonyms: 2-(4-(3,5-DIMETHOXYPHENYL)-YL)-2-PROPANOL;2-(3,5-DIMETHOXYPHENYL)PROPAN-2-OL;DDZ-OH;3,5-dimethoxy-alpha,alpha-dimethylbenzyl alcohol;3,5-dimethoxy-2,2-dimethylbenzene methanol;3,5-Dimethoxy-α,α-dimethylbenzenemethanol;2-(3,5-dimethoxyphenyl)-2-propanol
• CAS NO: 39507-96-5
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.24
• EINECS: 254-476-1
• Product Categories: Benzene derivates
• Mol File: 39507-96-5.mol

Chemical Properties

• Boiling Point: 307.1 °C at 760 mmHg
• Flash Point: 139.5 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 0.000323mmHg at 25°C
• Refractive Index: 1.504
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(3,5-Dimethoxyphenyl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-Dimethoxyphenyl)propan-2-ol(39507-96-5)
• EPA Substance Registry System: 2-(3,5-Dimethoxyphenyl)propan-2-ol(39507-96-5)

Safety Data

• Hazardous Substances Data: 39507-96-5(Hazardous Substances Data)

Usage

Uses

Used in Recreational Settings:
2-(3,5-Dimethoxyphenyl)propan-2-ol is used as a hallucinogen for its ability to induce psychedelic experiences, which include visual and auditory hallucinations, as well as altered perceptions of time, space, and consciousness.
Used in Research and Therapeutic Applications:
In the scientific community, 2-(3,5-Dimethoxyphenyl)propan-2-ol is utilized as a subject of study for its potential therapeutic effects, particularly in the treatment of mental health disorders. The exploration of its applications aims to understand and harness its properties for beneficial uses while managing the associated risks of abuse and dependence.

InChI:InChI=1/C11H16O3/c1-11(2,12)8-5-9(13-3)7-10(6-8)14-4/h5-7,12H,1-4H3

Upstream product

• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 17275-82-0 ethyl 3,5-dimethoxybenzoate 
• 74-88-4 methyl iodide 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 39508-00-4 3,5-dimethoxy-α,α-dimethylbenzylcarbazate 
• 39507-97-6 (α,α-dimethyl-3,5-dimethoxybenzyl)-phenylcarbonate 
• 135841-34-8 C₁₁H₁₅ClO₂ 
• 39508-07-1 Ddz-L-Phe-OH 
• 47555-19-1 (S)-3-tert-Butoxy-2-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethoxycarbonylamino]-propionic acid 
• 39508-02-6 (R)-3-{(R)-2-Carboxy-2-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethoxycarbonylamino]-ethyldisulfanyl}-2-[1-(3,5-dimethoxy-phenyl)-1-methyl-ethoxycarbonylamino]-propionic acid 
• 39508-04-8 Ddz-L-Ala-OH 
• 39508-01-5 (3’,5’-dimethoxy-1,1-dimethylbenzyloxy)carbonyl azide 
• 39508-15-1 3,5-dimethoxy-α-methylstyrene 
• 47121-49-3 Ddz-L-Gly-OH 
• 120078-19-5 4-(3,5-Dimethoxy-phenyl)-3-(3,4-dimethoxy-phenyl)-4-methyl-pentanoic acid methyl ester 
• 120078-16-2 3-(3,4-dimethoxyphenyl)-6,8-dimethoxy-4,4-dimethyl-3,4-dihydro-1(2H)-naphthalenone 
• 120116-27-0 2-(3,5-Dimethoxy-phenyl)-1-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol 
• 120078-30-0 2-(3,5-dimethoxyphenyl)-2-methylpropanal 

Relevant articles and documents

Access to "friedel-Crafts-Restricted" tert -alkyl aromatics by activation/methylation of tertiary benzylic alcohols

Herein we describe a two-step protocol to prepare m-tert-alkylbenzenes. The appropriate tertiary benzylic alcohols are activated with SOCl2 or concentrated HCl and then treated with trimethylaluminum, affording the desired products in 68-97% yields (22 examples). This reaction sequence is successful in the presence of a variety of functional groups, including acid-sensitive and Lewis-basic groups. In addition to t-Bu groups, 1,1-dimethylpropyl and 1-ethyl-1-methylpropyl groups can also be installed using this method.

Chromanol derivatives - A novel class of CETP inhibitors

Based on our former development candidate BAY 38-1315, optimization efforts led to the discovery of a novel chemical class of orally active cholesteryl ester transfer protein (CETP) inhibitors. The chromanol derivative 19b is a highly potent CETP inhibitor with favorable pharmacokinetic properties suitable for clinical studies. Chemical process optimization furnished a robust synthesis for a kilogram-scale process.

SYNTHESIS OF A CARBOCYCLIC ANALOG OF QUERCETIN VIA A BARBIER REACTION

A six-step synthetic route to the carbocyclic flavonoid 2 is described.The key step involves a 1,4-addition of a tertiary bromide to a α,β-unsaturated ester by the Barbier reaction.

Antiestrogens. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 1,1,2,2-Tetraalkyl-1,2-diphenylethanes

Among the newly synthesized 1,1,2,2-tetraalkyl-1,2-diphenylethanes, 1,1,2,2-tetramethyl-1,2-bis(4'-hydroxyphenyl)ethane (23) and 1,1,2,2-tetramethyl-1,2-bis(3'-hydroxyphenyl)ethane (26) were the most active compounds regarding estradiol receptor affinity, exhibiting Ka values of 0.73*108 and 0.67*108 M-1, respectively.In vivo, 23 and 26 showed only very small uterotrophic activity in the mouse.They strongly inhibited (73percent) the estrone-stimulated mouse uterine growth.Tested on the 9,10-dimethyl-1,2-benzanthracene induced hormone-dependent mammary adenocarcinoma of the Sprague-Dawley rat, compounds 23 and 26 exhibited a dose-dependent inhibition of the tumor growth, having a strong effect at a dose of 20 (mg/kg)/day (compound 23).