1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one

Base Information

Chemical Name:1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one
CAS No.:620534-54-5
Molecular Formula:C₂₁H₂₂ClF₆N₃O₂Si
Molecular Weight:525.953
Hs Code.:

1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1<i>H</i>-[1,2,3]triazol-4-yl]-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-but-2-yn-1-one

Synonyms:1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one

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Chemical Property of 1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one

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Technology Process of 1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one

There total 4 articles about 1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 620534-41-0
1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazole-4-carbaldehyde

: C₉H₁₇BrMgOSi

: 620534-54-5
1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one

Guidance literature:: 1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazole-4-carbaldehyde; C₉H₁₇BrMgOSi; In tetrahydrofuran;

With manganese(IV) oxide; In toluene;
DOI:10.3987/COM-05-S(T)64

Reference yield:

: 620533-92-8
1-(azidomethyl)-3,5-bis(trifluoromethyl)benzene

: 620534-54-5
1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 87 percent / NaOEt / ethanol

2.1: 70 percent / PCl₅ / toluene

3.1: LiBH₄ / tetrahydrofuran

3.2: 91 percent / Dess-Martin periodinane / CH₂Cl₂

4.1: tetrahydrofuran

4.2: 88 percent / MnO₂ / toluene

With lithium borohydride; phosphorus pentachloride; sodium ethanolate; In tetrahydrofuran; ethanol; toluene; 3.2: Dess-Martin oxidation;
DOI:10.3987/COM-05-S(T)64

Reference yield:

: 620534-09-0
1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

: 620534-54-5
1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiBH₄ / tetrahydrofuran

1.2: 91 percent / Dess-Martin periodinane / CH₂Cl₂

2.1: tetrahydrofuran

2.2: 88 percent / MnO₂ / toluene

With lithium borohydride; In tetrahydrofuran; 1.2: Dess-Martin oxidation;
DOI:10.3987/COM-05-S(T)64