3-chloro-5-((1-((6-methoxypyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Base Information

Chemical Name:3-chloro-5-((1-((6-methoxypyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile
CAS No.:1591827-08-5
Molecular Formula:C₁₈H₁₁ClF₃N₅O₃
Molecular Weight:437.765
Hs Code.:

Synonyms:3-chloro-5-((1-((6-methoxypyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Chemical Property of 3-chloro-5-((1-((6-methoxypyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Chemical Property:

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Technology Process of 3-chloro-5-((1-((6-methoxypyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

There total 10 articles about 3-chloro-5-((1-((6-methoxypyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1591827-00-7
3-chloro-5-((6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 1591827-10-9
(6-methoxypyridazin-3-yl)methyl methanesulfonate

: 1591827-08-5
3-chloro-5-((1-((6-methoxypyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

: 1591827-00-7
3-chloro-5-((6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 1591827-10-9
(6-methoxypyridazin-3-yl)methyl methanesulfonate

: 124-63-0
methanesulfonyl chloride

: 89532-79-6
3-hydroxymethyl-6-methoxypyridazine

: 1591827-08-5
3-chloro-5-((1-((6-methoxypyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: With triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1591826-98-0
5-bromo-3-(4-methoxybenzyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one

: 1591827-08-5
3-chloro-5-((1-((6-methoxypyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate

2: acetonitrile; water

3: triethylamine / N,N-dimethyl-formamide; dichloromethane; ethyl acetate

With potassium carbonate; triethylamine; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;