2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-methyl-carbamoyl]-cyclopentylmethyl}-pentanoic acid benzyl ester

Base Information

Chemical Name:2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-methyl-carbamoyl]-cyclopentylmethyl}-pentanoic acid benzyl ester
CAS No.:906070-00-6
Molecular Formula:C₃₂H₃₈N₂O₄
Molecular Weight:514.665
Hs Code.:

Synonyms:2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-methyl-carbamoyl]-cyclopentylmethyl}-pentanoic acid benzyl ester

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Chemical Property of 2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-methyl-carbamoyl]-cyclopentylmethyl}-pentanoic acid benzyl ester

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Technology Process of 2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-methyl-carbamoyl]-cyclopentylmethyl}-pentanoic acid benzyl ester

There total 10 articles about 2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-methyl-carbamoyl]-cyclopentylmethyl}-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 337962-88-6
2-[1-(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-ylcarbamoyl)-cyclopentylmethyl]-pentanoic acid benzyl ester

: 74-88-4
methyl iodide

: 906070-00-6
2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-methyl-carbamoyl]-cyclopentylmethyl}-pentanoic acid benzyl ester

Guidance literature:: 2-[1-(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-ylcarbamoyl)-cyclopentylmethyl]-pentanoic acid benzyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 3.5h;
DOI:10.1021/jm060133g

Reference yield:

: 1-(2-benzyloxycarbonyl-pent-4-enyl)-cyclopentanecarboxylic acid

: 906070-00-6
2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-methyl-carbamoyl]-cyclopentylmethyl}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / Pd/C / ethanol / 6 h / 1551.44 Torr

2.1: 53 percent / N-methylmorpholine; HOBt; (1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / 100 °C

3.1: NaH / tetrahydrofuran / 1 h / 0 °C

3.2: 21 percent / tetrahydrofuran / 3.5 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogen; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm060133g

Reference yield:

: 3400-45-1
cyclopentanecarboxylic acid

: 906070-00-6
2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridin-3-yl)-methyl-carbamoyl]-cyclopentylmethyl}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran; hexane / 2.5 h / -20 - 20 °C

1.2: tetrahydrofuran; hexane / 2 h / 20 °C

2.1: LDA / tetrahydrofuran; hexane / 0.67 h / -65 °C

2.2: tetrahydrofuran; hexane / 6 h / 20 °C

3.1: H₂ / Pd/C / ethanol / 6 h / 1551.44 Torr

4.1: 53 percent / N-methylmorpholine; HOBt; (1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / 100 °C

5.1: NaH / tetrahydrofuran / 1 h / 0 °C

5.2: 21 percent / tetrahydrofuran / 3.5 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogen; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm060133g