tert-butyl (2-methoxy-4-(piperidin-4-yl)phenyl)aminocarboxylate

Base Information

• Chemical Name: tert-butyl (2-methoxy-4-(piperidin-4-yl)phenyl)aminocarboxylate
• CAS No.: 1124330-12-6
• Molecular Formula: C₁₇H₂₆N₂O₃
• Molecular Weight: 306.405
• Mol file: 1124330-12-6.mol

Synonyms:tert-butyl (2-methoxy-4-(piperidin-4-yl)phenyl)aminocarboxylate

Chemical Property of tert-butyl (2-methoxy-4-(piperidin-4-yl)phenyl)aminocarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl (2-methoxy-4-(piperidin-4-yl)phenyl)aminocarboxylate

There total 4 articles about tert-butyl (2-methoxy-4-(piperidin-4-yl)phenyl)aminocarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 4-[3-methoxy-4-[(2-methylpropan-2-yl)oxycarbonyl-amino]phenyl]-3,6-dihydro-2H-pyridine-1-carboxylate (1124330-11-5) → tert-butyl (2-methoxy-4-(piperidin-4-yl)phenyl)aminocarboxylate (1124330-12-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 100 ℃; for 20h; under 7500.75 Torr;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (2-methoxy-4-(piperidin-4-yl)phenyl)aminocarboxylate (1124330-12-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 22 h / Inert atmosphere; Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 90 °C / Inert atmosphere

3: trifluoroacetic acid; hydrogen; acetic acid; platinum(IV) oxide / 20 °C

With platinum(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

(4-bromo-2-methoxyphenyl)carbamic acid tert-butyl ester (262433-01-2) → tert-butyl (2-methoxy-4-(piperidin-4-yl)phenyl)aminocarboxylate (1124330-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 90 °C / Inert atmosphere

2: trifluoroacetic acid; hydrogen; acetic acid; platinum(IV) oxide / 20 °C

With platinum(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; In 1,4-dioxane; water;

upstream raw materials:

benzyl 4-[3-methoxy-4-[(2-methylpropan-2-yl)oxycarbonyl-amino]phenyl]-3,6-dihydro-2H-pyridine-1-carboxylate

di-tert-butyl dicarbonate

(4-bromo-2-methoxyphenyl)carbamic acid tert-butyl ester

4-bromo-2-methoxyaniline

Downstream raw materials:

tert-butyl N-[2-methoxy-4-(1-methyl-4-piperidyl)phenyl]carbamate

4-(1-(2-fluoroethyl)piperidin-4-yl)-2-methoxyaniline