4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1H-pyrazole-3-carboxylic acid

Base Information

• Chemical Name: 4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1H-pyrazole-3-carboxylic acid
• CAS No.: 896466-71-0
• Molecular Formula: C₉H₁₃N₃O₄
• Molecular Weight: 227.22
• Mol file: 896466-71-0.mol

Synonyms:4-tert-butoxycarbonylamino-1H-pyrazole-3-carboxylic acid

Chemical Property of 4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1H-pyrazole-3-carboxylic acid

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

4-[[(1,1-Dimethylethoxy)carbonyl]amino]-1h-pyrazole-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1H-pyrazole-3-carboxylic acid

There total 5 articles about 4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

conc. aqueous HCl + (BOC)20 + methyl 4-amino-1H-pyrazole-3-carboxylate (360056-45-7) → 4-tert-butoxycarbonylamino-1H-pyrazole-3-carboxylic acid (896466-71-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water;

Reference yield: 85.4%

di-tert-butyl dicarbonate (24424-99-5) + methyl 4-amino-1H-pyrazole-3-carboxylate (360056-45-7) → 4-tert-butoxycarbonylamino-1H-pyrazole-3-carboxylic acid (896466-71-0)

Guidance literature:

methyl 4-amino-1H-pyrazole-3-carboxylate; With sodium hydroxide; water; In 1,4-dioxane; at 15 - 55 ℃; for 5h;

di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 20 - 55 ℃; for 1.08333 - 19h;

With hydrogenchloride; water; pH=~ 2;

Reference yield: 85.4%

di-tert-butyl dicarbonate (24424-99-5) → 4-tert-butoxycarbonylamino-1H-pyrazole-3-carboxylic acid (896466-71-0)

Guidance literature:

methyl 4-amino-1H-pyrazole-3-carboxylate; With sodium hydroxide; In 1,4-dioxane; water; at 15 - 55 ℃; for 5h;

di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 50 - 55 ℃; for 2 - 19h;

With hydrogenchloride; In water; pH=2; Product distribution / selectivity;

upstream raw materials:

di-tert-butyl dicarbonate

carbamic acid, phenyl-, 1-methylethyl ester

methyl 4-amino-1H-pyrazole-3-carboxylate

Downstream raw materials:

[3-(2-amino-4-morpholin-4-ylmethyl-phenylcarbamoyl)-1H-pyrazol-4-yl]-carbamic acid tert-butyl ester

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