360056-45-7

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrazole-3-carboxylic acid, 4-amino-, methyl ester (9CI) is used as a key intermediate in the synthesis of pharmaceuticals for its anti-cancer, anti-inflammatory, and anti-microbial properties. Its ability to inhibit the activity of certain enzymes makes it a valuable tool in biochemical research and drug discovery.
Used in Agrochemical Industry:
In the agrochemical industry, 1H-Pyrazole-3-carboxylic acid, 4-amino-, methyl ester (9CI) is used as a building block in the production of various organic compounds, contributing to the development of effective and safe agrochemical products.
Used in Dye Industry:
1H-Pyrazole-3-carboxylic acid, 4-amino-, methyl ester (9CI) is utilized in the dye industry for its potential applications in the synthesis of dyes with specific properties, enhancing the color range and performance of dyes in various applications.

Upstream product

• 138786-86-4 methyl 4-nitro-1H-pyrazole-3-carboxylate 
• 138786-86-4 4-nitro-2H-pyrazole-3-carboxylic acid methyl ester 

Downstream Products

• 906087-50-1 4-amino-pyrazole-3-carboxylic acid methyl-amide 
• 825619-04-3 4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxylic acid 
• 825619-05-4 methyl 4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxylate 
• 896467-54-2 4-(2,6-difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid methyl ester 
• 1024499-62-4 methyl 4-{[3-({[2-fluoro-5-(trifluoromethyl)phenyl]carbamoyl}amino)-benzyl]amino}-1H-pyrazole-3-carboxylate trifluoroacetate 
• 896466-71-0 4-tert-butoxycarbonylamino-1H-pyrazole-3-carboxylic acid 
• 27321-50-2 4-[3,3-dimethyltriaz-1-en-1-yl]-1H-pyrazol-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Discovery of novel cyclin-dependent kinase (CDK) and histone deacetylase (HDAC) dual inhibitors with potent in vitro and in vivo anticancer activity

In the current study, we reported a series of novel 1-H-pyrazole-3-carboxamide-based inhibitors targeting histone deacetylase (HDAC) and cyclin-dependent kinase (CDK). The representative compounds N-(4-((2-aminophenyl)carbamoyl)benzyl)-4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxamide (7c) and N-(4-(2-((2-aminophenyl)amino)-2-oxoethyl)phenyl)-4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxamide (14a) with potent antiproliferative activities towards five solid cancer cell lines, showed excellent inhibitory activities against HDAC2 (IC50 = 0.25 and 0.24 nM respectively) and CDK2 (IC50 = 0.30 and 0.56 nM respectively). In addition, compounds 7c and 14a significantly inhibited the migration of A375 and H460 cells. Further studies revealed that compounds 7c and 14a could arrest cell cycle in G2/M phase and promote apoptosis in A375, HCT116, H460 and Hela cells, which was associated with increasing the intracellular reactive oxygen species (ROS) levels. More importantly, compound 7c possessed favorable pharmacokinetic properties with the intraperitoneal bioavailability of 63.6% in ICR mice, and potent in vivo antitumor efficacy in the HCT116 xenograft model. Our study demonstrated that compound 7c provides a promising strategy for the treatment of malignant tumors.

1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS

Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS

Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

ATR inhibitors and application thereof in medicines

The invention relates to novel compounds represented by a formula (I). The novel compounds have ATR regulating activity. The invention also relates to a preparation method of the compounds and a pharmaceutical composition containing the compounds.

5-MORPHOLIN-4-YL-PYRAZOLO[4,3-B]PYRIDINE DERIVATIVES

Compounds of the formula Ia and Ib in which R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of ATR, and can be employed for the treatment of diseases such as cancer.

Pyrazolecarboxamide derivatives and application thereof

The invention relates to pyrazolecarboxamide derivatives or pharmaceutically acceptable salt or precursors thereof. The structure of the pyrazolecarboxamide derivatives is shown in the general formula (I) in the specification, wherein R1 is selected from

The design and synthesis of potent and selective inhibitors of trypanosoma brucei glycogen synthase kinase 3 for the treatment of human African trypanosomiasis

Glycogen synthase kinase 3 (GSK3) is a genetically validated drug target for human African trypanosomiasis (HAT), also called African sleeping sickness. We report the synthesis and biological evaluation of aminopyrazole derivatives as Trypanosoma brucei G

COMBINATIONS OF PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDKS AND GSK'S

A combination comprising (a) a compound of formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C═O, NR9

Diversity-oriented synthesis of substituted pyrazolo-[4,3-d][1,2,3]triazin-4-ones

An efficient synthesis of 3,7-disubstituted 3,5-dihydro-4H-pyrazolo-[4,3-d][1,2,3]triazin-4-ones (2), especially suited for late-stage decoration, is described. Diverse 3-benzyl analogs were obtained by amidation-cyclization in one pot and various pyrazol

Pyrazole Compound

The present invention provides a pyrazole compound represented by the formula (I): wherein ring A0 is a pyrazole ring optionally further having 1 or 2 substituents; Ra is a substituted carbamoyl group; and Rb is an optionally substituted acylamino group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of GSK-3β related pathology or disease, and a GSK-3β inhibitor including same.