2-[(1-amino-cyclohexanecarbonyl)-amino]-N¹-[3-(5-methyl-indol-1-yl)-propyl]-succinamide

Base Information

• Chemical Name: 2-[(1-amino-cyclohexanecarbonyl)-amino]-N¹-[3-(5-methyl-indol-1-yl)-propyl]-succinamide
• CAS No.: 264131-77-3
• Molecular Formula: C₂₃H₃₃N₅O₃
• Molecular Weight: 427.547

Synonyms:2-[(1-amino-cyclohexanecarbonyl)-amino]-N¹-[3-(5-methyl-indol-1-yl)-propyl]-succinamide

Chemical Property of 2-[(1-amino-cyclohexanecarbonyl)-amino]-N¹-[3-(5-methyl-indol-1-yl)-propyl]-succinamide

Chemical Property:

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Technology Process of 2-[(1-amino-cyclohexanecarbonyl)-amino]-N¹-[3-(5-methyl-indol-1-yl)-propyl]-succinamide

There total 3 articles about 2-[(1-amino-cyclohexanecarbonyl)-amino]-N¹-[3-(5-methyl-indol-1-yl)-propyl]-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-{2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (264131-76-2) → 2-[(1-amino-cyclohexanecarbonyl)-amino]-N1-[3-(5-methyl-indol-1-yl)-propyl]-succinamide (264131-77-3)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide;

DOI:10.1021/jm9904248

Reference yield:

1-[((9H-fluoren-9-yl)methoxy)carbonylamino]cyclohexanecarboxylic acid (162648-54-6) → 2-[(1-amino-cyclohexanecarbonyl)-amino]-N1-[3-(5-methyl-indol-1-yl)-propyl]-succinamide (264131-77-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HOBt*H₂O; DIPCDI / dimethylformamide / 1 h / 20 °C

1.2: 96 percent / dimethylformamide / 20 °C

2.1: piperidine / dimethylformamide

With piperidine; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; In N,N-dimethyl-formamide; 1.1: Condensation / 1.2: Condensation / 2.1: Deprotection;

DOI:10.1021/jm9904248

Reference yield:

3-(N-(5-methylindolyl))propanamido-L-asparagine → 2-[(1-amino-cyclohexanecarbonyl)-amino]-N1-[3-(5-methyl-indol-1-yl)-propyl]-succinamide (264131-77-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HOBt*H₂O; DIPCDI / dimethylformamide / 1 h / 20 °C

1.2: 96 percent / dimethylformamide / 20 °C

2.1: piperidine / dimethylformamide

With piperidine; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; In N,N-dimethyl-formamide; 1.1: Condensation / 1.2: Condensation / 2.1: Deprotection;

DOI:10.1021/jm9904248

upstream raw materials:

(1-{2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

1-[((9H-fluoren-9-yl)methoxy)carbonylamino]cyclohexanecarboxylic acid

Downstream raw materials:

{4-[2-(1-{2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

N-{1-(1-{2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester

{4-[(S)-2-Amino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

{4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

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