1,2-Dihydro-4,6-dimethyl-2-(2-N-benzoylhydroxylaminophenyl)-pyridin-3,5-dicarbonsaeuredimethylester

Base Information

• Chemical Name: 1,2-Dihydro-4,6-dimethyl-2-(2-N-benzoylhydroxylaminophenyl)-pyridin-3,5-dicarbonsaeuredimethylester
• CAS No.: 133148-10-4
• Molecular Formula: C₂₄H₂₄N₂O₆
• Molecular Weight: 436.464
• Mol file: 133148-10-4.mol

Synonyms:1,2-Dihydro-4,6-dimethyl-2-(2-N-benzoylhydroxylaminophenyl)-pyridin-3,5-dicarbonsaeuredimethylester

Chemical Property of 1,2-Dihydro-4,6-dimethyl-2-(2-N-benzoylhydroxylaminophenyl)-pyridin-3,5-dicarbonsaeuredimethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Dihydro-4,6-dimethyl-2-(2-N-benzoylhydroxylaminophenyl)-pyridin-3,5-dicarbonsaeuredimethylester

There total 2 articles about 1,2-Dihydro-4,6-dimethyl-2-(2-N-benzoylhydroxylaminophenyl)-pyridin-3,5-dicarbonsaeuredimethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

1,2-Dihydro-4,6-dimethyl-2-(2-hydroxylaminophenyl)-pyridin-3,5-dicarbonsaeuredimethylester (133148-08-0) + benzoyl chloride (98-88-4) → 1,2-Dihydro-4,6-dimethyl-2-(2-N-benzoylhydroxylaminophenyl)-pyridin-3,5-dicarbonsaeuredimethylester (133148-10-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 50 ℃; for 1h;

DOI:10.1002/ardp.19913240208

Reference yield:

dimethyl 4,6-dimethyl-2-(2-nitrophenyl)-1,2-dihydropyridine-3,5-dicarboxylate (108139-80-6) → 1,2-Dihydro-4,6-dimethyl-2-(2-N-benzoylhydroxylaminophenyl)-pyridin-3,5-dicarbonsaeuredimethylester (133148-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / Zn dust, NH₄Cl / ethanol; H₂O / 18 h / Ambient temperature

2: 22 percent / triethylamine / tetrahydrofuran / 1 h / 50 °C

With ammonium chloride; triethylamine; zinc; In tetrahydrofuran; ethanol; water;

DOI:10.1002/ardp.19913240208

upstream raw materials:

1,2-Dihydro-4,6-dimethyl-2-(2-hydroxylaminophenyl)-pyridin-3,5-dicarbonsaeuredimethylester

benzoyl chloride

dimethyl 4,6-dimethyl-2-(2-nitrophenyl)-1,2-dihydropyridine-3,5-dicarboxylate