Cbz(L-Phe)Aib₄OH

Base Information

Chemical Name:Cbz(L-Phe)Aib₄OH
CAS No.:1187839-12-8
Molecular Formula:C₃₃H₄₅N₅O₈
Molecular Weight:639.749
Hs Code.:

Synonyms:Cbz(L-Phe)Aib₄OH

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Chemical Property of Cbz(L-Phe)Aib₄OH

Chemical Property:

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Technology Process of Cbz(L-Phe)Aib₄OH

There total 3 articles about Cbz(L-Phe)Aib₄OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1187839-07-1
Cbz(L-Phe)(α-aminoisobutyric acid₎₄OtBu

: 1187839-12-8
Cbz(L-Phe)Aib₄OH

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/anie.200901892

Reference yield:

: 1187839-02-6
N₃(α-aminoisobutyric acid)₄OtBu

: 1187839-12-8
Cbz(L-Phe)Aib₄OH

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / methanol

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / Inert atmosphere

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1039/c2cc00060a

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 1187839-12-8
Cbz(L-Phe)Aib₄OH

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 12 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/chem.201302648