(R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid

Base Information

Chemical Name:(R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid
CAS No.:950505-79-0
Molecular Formula:C₂₆H₂₄O₂
Molecular Weight:368.475
Hs Code.:

Synonyms:(R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid

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Chemical Property of (R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid

Chemical Property:

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Technology Process of (R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid

There total 6 articles about (R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 950505-77-8
(R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester

: 950505-78-9
(R/S)-[6-(1-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester

: 950505-79-0
(R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid

: 950504-81-1
(R/S)-[6-(1-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid

Guidance literature:: (R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester; (R/S)-[6-(1-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid ethyl ester; With lithium hydroxide; water; In tetrahydrofuran; ethanol; at 20 ℃; for 6h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water; pH=2 - 3;

Reference yield:

: 805250-12-8
(R/S)-(6-Hydroxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid ethyl ester

: 950505-79-0
(R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 20 h / 0 - 20 °C

2.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / N,N-dimethyl-formamide / 115 °C

3.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 6 h / 20 °C

3.2: pH 2 - 3

With lithium hydroxide; water; triethylamine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 139149-06-7
6-(4-methoxy-benzyloxy)-3,4-dihydro-2H-naphthalen-1-one

: 950505-79-0
(R/S)-[6-((E)-2-biphenyl-4-yl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2.33 h / -78 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: triethylamine / dichloromethane / 20 h / 0 - 20 °C

4.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / N,N-dimethyl-formamide / 115 °C

5.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 6 h / 20 °C

5.2: pH 2 - 3

With lithium hydroxide; water; hydrogen; triethylamine; lithium hexamethyldisilazane; palladium diacetate; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;