ethyl 4-[(2-amino-4-fluorophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate

Base Information

Chemical Name:ethyl 4-[(2-amino-4-fluorophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate
CAS No.:1031337-91-3
Molecular Formula:C₂₆H₃₀FN₃O₃
Molecular Weight:451.541
Hs Code.:

Synonyms:ethyl 4-[(2-amino-4-fluorophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-[(2-amino-4-fluorophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate

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Technology Process of ethyl 4-[(2-amino-4-fluorophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate

There total 2 articles about ethyl 4-[(2-amino-4-fluorophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1031337-80-0
ethyl 4-[(4-fluoro-2-nitrophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate

: 1031337-91-3
ethyl 4-[(2-amino-4-fluorophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate

Guidance literature:: With 10% Pd/C; hydrogen; In ethanol;
DOI:10.1016/j.bmcl.2008.05.075

Reference yield:

: 1031337-91-3
ethyl 4-[(2-amino-4-fluorophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate

Guidance literature:

Reference yield: 89.0%

: 59-67-6
nicotinic acid

: 1031337-91-3
ethyl 4-[(2-amino-4-fluorophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate

: 1054611-28-7
C₃₂H₃₃FN₄O₄

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmcl.2008.05.075