Technology Process of rac-N-{1-[(phenyl)methyl]piperidin-4-yl}-2-{2-[(2,6-diethoxyphenoxy)methyl]phenyl}-2-hydroxypropanamide
There total 6 articles about rac-N-{1-[(phenyl)methyl]piperidin-4-yl}-2-{2-[(2,6-diethoxyphenoxy)methyl]phenyl}-2-hydroxypropanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-amino-1-benzylpiperidine; 2-{2-[(2,6-diethoxyphenoxy)methyl]phenyl}-2-hydroxypropanoic acid;
With
4-methyl-morpholine; benzotriazol-1-ol;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.5h;
Inert atmosphere;
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1135/cccc2011017
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 - 0 °C / Inert atmosphere
2.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 16 h
3.1: 4-methyl-morpholine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
3.2: 16 h / 0 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide;
In
dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
1.2: Swern oxidation;
DOI:10.1135/cccc2011017
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 16 h
2.1: 4-methyl-morpholine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
2.2: 16 h / 0 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-ol;
In
water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1135/cccc2011017
