(2R)-N-(5-cyclopropyl-1-hydroxy-pyridin-3-ylmethyl)-3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide

Base Information

• Chemical Name: (2R)-N-(5-cyclopropyl-1-hydroxy-pyridin-3-ylmethyl)-3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide
• CAS No.: 1021018-02-9
• Molecular Formula: C₁₈H₁₇F₃N₂O₂
• Molecular Weight: 350.34
• Mol file: 1021018-02-9.mol

Synonyms:(2R)-N-(5-cyclopropyl-1-hydroxy-pyridin-3-ylmethyl)-3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide

Chemical Property of (2R)-N-(5-cyclopropyl-1-hydroxy-pyridin-3-ylmethyl)-3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-N-(5-cyclopropyl-1-hydroxy-pyridin-3-ylmethyl)-3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide

There total 1 articles about (2R)-N-(5-cyclopropyl-1-hydroxy-pyridin-3-ylmethyl)-3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C-(5-cyclopropyl-pyridin-3-yl)-methylamine (852877-60-2) + (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid (17257-70-4) → (2R)-N-(5-cyclopropyl-1-hydroxy-pyridin-3-ylmethyl)-3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide (1021018-02-9)

Guidance literature:

C-(5-cyclopropyl-pyridin-3-yl)-methylamine; (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.166667h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; for 3h;

Reference yield:

(2R)-N-(5-cyclopropyl-1-hydroxy-pyridin-3-ylmethyl)-3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide (1021018-02-9) → (2R)-N-(5-cyclopropyl-1-hydroxy-pyridin-3-ylmethyl)-3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide hyrochloride (1020747-82-3)

Guidance literature:

With hydrogenchloride; In water;

upstream raw materials:

C-(5-cyclopropyl-pyridin-3-yl)-methylamine

(R)-α-hydroxy-α-trifluoromethylphenyl acetic acid

Downstream raw materials:

(2R)-N-(5-cyclopropyl-1-hydroxy-pyridin-3-ylmethyl)-3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide hyrochloride