(R)-α-hydroxy-α-trifluoromethylphenyl acetic acid

Base Information

• Chemical Name: (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid
• CAS No.: 17257-70-4
• Molecular Formula: C₉H₇F₃O₃
• Molecular Weight: 220.148
• Mol file: 17257-70-4.mol

Synonyms:(R)-α-hydroxy-α-trifluoromethylphenyl acetic acid

Chemical Property of (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid

There total 6 articles about (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(S)-1,1,1-trifluoro-2-phenylbut-3-ene-2-ol (152141-78-1) → (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid (17257-70-4)

Guidance literature:

(S)-1,1,1-trifluoro-2-phenylbut-3-ene-2-ol; With dimethylsulfide; ozone; In methanol;

With sodium chlorite; isoprene; In tert-butyl alcohol;

DOI:10.1016/j.tetlet.2006.09.048

Reference yield: 72.0%

(-)-(2R)-3,3,3-trifluoro-2-phenylpropane-1,2-diol (159383-84-3) → (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid (17257-70-4)

Guidance literature:

With oxygen; sodium hydrogencarbonate; platinum on activated charcoal; at 75 ℃; for 20h;

DOI:10.1016/0957-4166(94)80116-9

Reference yield:

3,3,3-trifluoro-2-hydroxy-2-phenylpropanoic acid (55519-22-7) → (R)-α-hydroxy-α-trifluoromethylphenyl acetic acid (17257-70-4)

Guidance literature:

In methanol; ethanol; hexane; diethylamine; Resolution of racemate;

upstream raw materials:

(-)-(2R)-3,3,3-trifluoro-2-phenylpropane-1,2-diol

(S)-1,1,1-trifluoro-2-phenylbut-3-ene-2-ol

2,2,2-Trifluoroacetophenone

3,3,3-trifluoro-2-phenylpropene

Downstream raw materials:

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

(R)-(-)-α-methoxy-α-trifluoromethylphenylacetyl chloride

3,3,3-trifluoro-2-hydroxy-2-phenyl-N-{[5-(trifluoromethyl)pyridin-3-yl]methyl}propanamide

(2R)-3,3,3-trifluoro-2-hydroxy-2-phenyl-N-{[4-(trifluoromethyl)pyridin-2-yl]methyl}propanamide

Refernces

• 1、 Gosselin, Francis,Britton, Robert A.,Mowat, Jeffrey,O'Shea, Paul D.,Davies, Ian W.. "Asymmetric organozincate additions to ethyl 2,2,2-trifluoropyruvate". . p. 2193 - 2196. Retrieved 2008/02/10.
• 2、 Bennani,Vanhessche,Sharpless. "A short route to a Mosher's acid precursor via catalytic asymmetric dihydroxylation (AD)". . p. 1473 - 1476. Retrieved 2007/10/02.