3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1450642-41-7
Molecular Formula:C₂₁H₁₇FN₆
Molecular Weight:372.405
Hs Code.:

Synonyms:3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

There total 11 articles about 3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450642-93-9
3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1Hpyrrolo[2,3-b] pyridine

: 1450642-41-7
3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 15h;
DOI:10.1016/j.bmcl.2013.06.071

Reference yield:

: 1415825-05-6
1-(2-fluorobenzyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 1450642-41-7
3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / toluene; ethanol; water / 2 h / 100 °C

2: sodium carbonate / toluene; ethanol; water / 12 h / 100 °C

3: lithium hydroxide; water / tetrahydrofuran; methanol / 15 h / 25 °C

With water; sodium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; water; toluene;
DOI:10.1016/j.bmcl.2013.06.071

Reference yield:

: 1450642-73-5
5-bromo-3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b ]pyridine

: 1450642-41-7
3-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / toluene; ethanol; water / 12 h / 100 °C

2: lithium hydroxide; water / tetrahydrofuran; methanol / 15 h / 25 °C

With water; sodium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; water; toluene;
DOI:10.1016/j.bmcl.2013.06.071