tert-butyl [4-(2-{5-acetamido-3-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate

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Chemical Name:tert-butyl [4-(2-{5-acetamido-3-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate
CAS No.:1429659-48-2
Molecular Formula:C₂₅H₃₀N₄O₃S
Molecular Weight:466.604
Hs Code.:

Synonyms:tert-butyl [4-(2-{5-acetamido-3-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate

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Chemical Property of tert-butyl [4-(2-{5-acetamido-3-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate

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Technology Process of tert-butyl [4-(2-{5-acetamido-3-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate

There total 5 articles about tert-butyl [4-(2-{5-acetamido-3-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1289627-61-7
tert-butyl N-[4-(2-iodoethyl)phenyl]carbamate

: 1429659-46-0
N-{5-[4-(methylsulfanyl)phenyl]-1H-pyrazol-3-yl}acetamide

: 1429659-47-1
tert-butyl [4-(2-{3-acetamido-5-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate

: 1429659-48-2
tert-butyl [4-(2-{5-acetamido-3-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 55 ℃; Overall yield = 53 %; Overall yield = 696 mg; Inert atmosphere;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 1344045-96-0
3-[4-(methylsulfanyl)phenyl]-3-oxopropanenitrile

: 1429659-47-1
tert-butyl [4-(2-{3-acetamido-5-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate

: 1429659-48-2
tert-butyl [4-(2-{5-acetamido-3-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate; hydrogenchloride / water; ethanol / 2.5 h / Reflux

2.1: pyridine / 0.5 h / 0 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 55 °C / Inert atmosphere

With pyridine; hydrogenchloride; potassium carbonate; hydrazine hydrate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 42445-46-5
2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone

: 1429659-47-1
tert-butyl [4-(2-{3-acetamido-5-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate

: 1429659-48-2
tert-butyl [4-(2-{5-acetamido-3-[4-(methylsulfanyl)phenyl]-1H-pyrazol-1-yl}ethyl)phenyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; ethanol / 0 - 20 °C

2.1: hydrazine hydrate; hydrogenchloride / water; ethanol / 2.5 h / Reflux

3.1: pyridine / 0.5 h / 0 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 55 °C / Inert atmosphere

With pyridine; hydrogenchloride; potassium carbonate; hydrazine hydrate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.02.048