(R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-methylene-hexanoic acid

Base Information

Chemical Name:(R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-methylene-hexanoic acid
CAS No.:188729-12-6
Molecular Formula:C₁₈H₂₄N₂O₄
Molecular Weight:332.4
Hs Code.:

Synonyms:(R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-methylene-hexanoic acid

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Chemical Property of (R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-methylene-hexanoic acid

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Technology Process of (R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-methylene-hexanoic acid

There total 4 articles about (R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-methylene-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42990-28-3
(R)-2-bromo-4-methylpentanoic acid

: 188729-12-6
(R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-methylene-hexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 75.7 percent / H₂SO₄ / CH₂Cl₂ / 24 h / Ambient temperature

2: 49.6 percent / t-BuOK / dimethylformamide / 96 h / 0 - 5 °C

3: 61.5 percent / 95percent aq. CF₃COOH / Ambient temperature

4: 95 percent / HOBT, 4-aminopyridine, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide / dimethylformamide / Ambient temperature

5: 1.) ammonium formate, 2.) piperidine / 1.) 10percent Pd/C

With piperidine; 4-aminopyridine; sulfuric acid; potassium tert-butylate; ammonium formate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00028-X

Reference yield:

: 155947-71-0
benzyl 2<(benzyloxy)carbonyl>-3(R)-(hydroxycarbonyl)-5-methylhexanoate

: 188729-12-6
(R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-methylene-hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / HOBT, 4-aminopyridine, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide / dimethylformamide / Ambient temperature

2: 1.) ammonium formate, 2.) piperidine / 1.) 10percent Pd/C

With piperidine; 4-aminopyridine; ammonium formate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00028-X

Reference yield:

: 145660-99-7
2-Benzyloxycarbonyl-3R-isobutyl-succinic acid 4-tert-butyl ester 1-benzyl ester

: 188729-12-6
(R)-5-Methyl-3-[((S)-methylcarbamoyl-phenyl-methyl)-carbamoyl]-2-methylene-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 61.5 percent / 95percent aq. CF₃COOH / Ambient temperature

2: 95 percent / HOBT, 4-aminopyridine, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide / dimethylformamide / Ambient temperature

3: 1.) ammonium formate, 2.) piperidine / 1.) 10percent Pd/C

With piperidine; 4-aminopyridine; ammonium formate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00028-X