(5S,9S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-9-methyl-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

Base Information

Chemical Name:(5S,9S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-9-methyl-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate
CAS No.:1218927-37-7
Molecular Formula:C₂₈H₂₉N₃O₅
Molecular Weight:487.555
Hs Code.:

Synonyms:(5S,9S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-9-methyl-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S,9S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-9-methyl-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (5S,9S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-9-methyl-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

There total 7 articles about (5S,9S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-9-methyl-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 10065-72-2
L-Alanine methyl ester

: (9H-fluoren-9-yl)methyl (S)-(1-(hydroxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate

: 1218927-37-7
(5S,9S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-9-methyl-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

Guidance literature:: (9H-fluoren-9-yl)methyl (S)-(1-(hydroxyamino)-1-oxo-3-phenylpropan-2-yl)carbamate; With 4-methyl-morpholine; dimethylbromosulphonium bromide; In acetonitrile; for 1h; Reflux;

L-Alanine methyl ester; In acetonitrile;
DOI:10.1080/00304948.2019.1579039

Reference yield:

: 10065-72-2
L-Alanine methyl ester

: 611198-23-3
Fmoc-Phe-NCO

: 1218927-37-7
(5S,9S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-9-methyl-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

Guidance literature:: In tetrahydrofuran; dimethyl sulfoxide; Reflux;
DOI:10.1039/b920290k

Reference yield:

: 35661-40-6
N-Fmoc L-Phe

: 1218927-37-7
(5S,9S)-methyl 5-benzyl-1-(9H-fluoren-9-yl)-9-methyl-3,7-dioxo-2-oxa-4,6,8-triazadecan-10-oate

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -20 °C

2: sodium azide / tetrahydrofuran; water / 0.5 h

3: toluene / 65 °C / Inert atmosphere

4: 4-methyl-morpholine / dichloromethane / 25 °C

With 4-methyl-morpholine; sodium azide; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1002/jms.1862