(E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid 4-nitrophenyl ester

Base Information

• Chemical Name: (E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid 4-nitrophenyl ester
• CAS No.: 121458-58-0
• Molecular Formula: C₂₃H₂₃NO₅S
• Molecular Weight: 425.505

Synonyms:(E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid 4-nitrophenyl ester

Chemical Property of (E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid 4-nitrophenyl ester

Chemical Property:

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Technology Process of (E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid 4-nitrophenyl ester

There total 9 articles about (E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.3%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid (121458-57-9) → (E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid 4-nitrophenyl ester (121458-58-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00172a029

Reference yield:

1-bromo-2,2-dimethoxyheptane (129620-22-0) → (E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid 4-nitrophenyl ester (121458-58-0)

Guidance literature:

Multi-step reaction with 7 steps

1: H₂O / 1 h / Ambient temperature

2: H₂SO₄ / 0.5 h / -5 °C

3: dimethylformamide / 1.) RT, 3 h, 2.) 45 deg C, overnight

4: 10 N NaOH / 0.17 h / 110 °C

5: CH₂Cl₂ / 40 h / Ambient temperature

6: 2 N aq. NaOH / methanol / 1 h / Heating

7: 82.3 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; sulfuric acid; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00172a029

Reference yield:

6-methoxy-3-pentylbenzothiophene (121458-54-6) → (E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid 4-nitrophenyl ester (121458-58-0)

Guidance literature:

Multi-step reaction with 5 steps

1: dimethylformamide / 1.) RT, 3 h, 2.) 45 deg C, overnight

2: 10 N NaOH / 0.17 h / 110 °C

3: CH₂Cl₂ / 40 h / Ambient temperature

4: 2 N aq. NaOH / methanol / 1 h / Heating

5: 82.3 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00172a029

upstream raw materials:

4-nitro-phenol

(E)-3-(6-methoxy-3-pentylbenzo[b]thien-2-yl)-2-propenoic acid

1-bromo-2,2-dimethoxyheptane

6-methoxy-3-pentylbenzothiophene

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