N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(3-chloro-4-methoxyphenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

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Chemical Name:N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(3-chloro-4-methoxyphenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide
CAS No.:1609174-26-6
Molecular Formula:C₃₅H₄₃ClN₄O₅
Molecular Weight:635.203
Hs Code.:

Synonyms:N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(3-chloro-4-methoxyphenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(3-chloro-4-methoxyphenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

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Technology Process of N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(3-chloro-4-methoxyphenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

There total 13 articles about N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(3-chloro-4-methoxyphenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1609174-26-6
N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(3-chloro-4-methoxyphenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 24h; Molecular sieve;

Reference yield:

: C₁₈H₁₄Cl₂N₂O₃

: 457060-96-7
2-butoxy-4-(3-(diethylamino)propoxy)aniline

: 1609174-26-6
N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(3-chloro-4-methoxyphenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.03.072

Reference yield:

: C₁₈H₁₅ClN₂O₄

: 1609174-26-6
N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-(3-chloro-4-methoxyphenoxy)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 0 °C

2: triethylamine / tetrahydrofuran; dichloromethane / 1 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2014.03.072