9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

Base Information

Chemical Name:9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin
CAS No.:168427-72-3
Molecular Formula:C₂₈H₂₈Cl₄N₄O₆
Molecular Weight:658.366
Hs Code.:

Synonyms:9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

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Chemical Property of 9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

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Technology Process of 9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

There total 8 articles about 9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 168427-71-2
9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

: 6482-24-2
2-Bromoethyl methyl ether

: 168427-72-3
9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 60 ℃; for 9h;
DOI:10.1002/hlca.19950780219

Reference yield:

: 50-69-1
D-ribose

: 168427-72-3
9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) cc. H₂SO₄, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C

2: 125.9 g / SnCl₄ / CH₂Cl₂ / 35 h / 3 °C

3: pyridine, 4-(dimethylamino)-pyridine / 17 h

4: 63 percent / BSA, TfOSiMe₃ / 1,2-dichloro-ethane / 7 h / 70 °C

5: 96 percent / SOCl₂ / dimethylformamide; CH₂Cl₂ / 5.5 h / 55 °C

6: 90 percent / tetrahydrofuran; methanol / 3 h / Ambient temperature

7: 78 percent / NaH / tetrahydrofuran / 9 h / 60 °C

With pyridine; benzenesulfonamide; dmap; thionyl chloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; tin(IV) chloride; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19950780219

Reference yield:

: 94-99-5
2,4-Dichlorobenzyl chloride

: 168427-72-3
9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) cc. H₂SO₄, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C

2: 125.9 g / SnCl₄ / CH₂Cl₂ / 35 h / 3 °C

3: pyridine, 4-(dimethylamino)-pyridine / 17 h

4: 63 percent / BSA, TfOSiMe₃ / 1,2-dichloro-ethane / 7 h / 70 °C

5: 96 percent / SOCl₂ / dimethylformamide; CH₂Cl₂ / 5.5 h / 55 °C

6: 90 percent / tetrahydrofuran; methanol / 3 h / Ambient temperature

7: 78 percent / NaH / tetrahydrofuran / 9 h / 60 °C

With pyridine; benzenesulfonamide; dmap; thionyl chloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; tin(IV) chloride; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19950780219