2'-O-Moe-adenosine

Base Information

• Chemical Name: 2'-O-Moe-adenosine
• CAS No.: 168427-74-5
• Molecular Formula: C13H19N5O5
• Molecular Weight: 325.324
• Hs Code.: 2934999090
• Mol file: 168427-74-5.mol

Synonyms:2'-O-(2-METHOXYETHYL)ADENOSINE;

Chemical Property of 2'-O-Moe-adenosine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.72
• Boiling Point: 638.954 °C at 760 mmHg
• PKA: 13.12±0.70(Predicted)
• Flash Point: 340.227 °C
• PSA: 137.77000
• Density: 1.701 g/cm³
• LogP: -0.72810
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

2''-O-(2-Methoxyethyl)adenosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A adenosine derivative as building blocks for cross-linking oligonucleotides.

Technology Process of 2'-O-Moe-adenosine

There total 18 articles about 2'-O-Moe-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)adenosin (168427-73-4) → 2'-O-(2-methoxyethyl)adenosine (168427-74-5)

Guidance literature:

With hydrogen; magnesium oxide; palladium on activated charcoal; In methanol; at 45 ℃; for 65h; under 2250.2 Torr;

DOI:10.1002/hlca.19950780219

Reference yield: 84.0%

3',5'-di-O-levulinyl-2'-O-(2-methoxyethyl)adenosine (440327-54-8) → 2'-O-(2-methoxyethyl)adenosine (168427-74-5) + 3'-O-levulinyl-2'-O-(2-methoxyethyl)adenosine

Guidance literature:

With Candida antarctica lipase B; phosphate buffer; In 1,4-dioxane; at 40 ℃; for 36h; pH=7;

DOI:10.1021/jo020080k

Reference yield: 56.0%

2-methoxyethyl methanesulfonate (16427-44-4) + adenosine (58-61-7) → 2'-O-(2-methoxyethyl)adenosine (168427-74-5)

Guidance literature:

With 2-methoxy-ethanol; sodium hydroxide; In N,N-dimethyl-formamide; at 8 - 65 ℃; Large scale;

upstream raw materials:

3',5'-Bis-O-(2,4-dichlorobenzyl)-2'-O-(2-methoxyethyl)adenosin

2-iodo-1-methoxyethane

adenosine

3',5'-di-O-levulinyl-2'-O-(2-methoxyethyl)adenosine

Downstream raw materials:

5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-N6-benzoyladenosine

2'-O-methoxyethyl- N⁶-benzoyl -adenosine

Refernces

• 1、 -. "2 the [...] -O-(2- armor oxygen ethyl) adenosine and 2 the [...] -O-(2- armor oxygen ethyl) guanosine and its derivatives preparation and its purification method". Paragraph 0162; 0163. . Retrieved 2016/10/07.
• 2、 Sivets, Grigorii G.. "Synthesis study of 2′-O-(2-methoxyethyl)-purine derivatives". . p. 1237 - 1240. Retrieved 2008/09/18.