(3R,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

Base Information

Chemical Name:(3R,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate
CAS No.:1360572-06-0
Molecular Formula:C₂₃H₃₄O₅
Molecular Weight:390.52
Hs Code.:

Synonyms:(3R,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

Suppliers and Price of (3R,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

There total 11 articles about (3R,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: (2S,3R,4R)-3-((4-methoxybenzyl)oxy)-2,4-dimethylhept-5-ynal

: 1360572-06-0
(3R,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

: 1360572-20-8
(3S,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

Guidance literature:: acetic acid tert-butyl ester; With n-butyllithium; Glucose; diisopropylamine; In diethyl ether; hexane; at -78 - -30 ℃; for 2.15h; Inert atmosphere;

(2S,3R,4R)-3-((4-methoxybenzyl)oxy)-2,4-dimethylhept-5-ynal; In diethyl ether; hexane; at -105 - -78 ℃; for 15.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201106762

Reference yield:

: (2S,3R,4R)-3-((4-methoxybenzyl)oxy)-2,4-dimethylhept-5-ynal

: 93215-51-1
1-tert-butoxy-1-(trimethylsiloxy)ethylene

: 1360572-06-0
(3R,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

: 1360572-20-8
(3S,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

Guidance literature:: With boron trifluoride diethyl etherate; In toluene; at -78 ℃; for 0.5h; optical yield given as %de; Inert atmosphere;
DOI:10.1002/anie.201106762

Reference yield:

: 883877-37-0
(2R,3R,4R)-3-(p-methoxybenzyloxy)-2,4-dimethyl-5-heptyn-1-ol

: 1360572-06-0
(3R,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

: 1360572-20-8
(3S,4R,5R,6R)-tert-butyl 3-hydroxy-5-((4-methoxybenzyl)oxy)-4,6-dimethylnon-7-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.58 h / -78 - -40 °C / Inert atmosphere

1.2: -40 - 20 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / toluene / 0.5 h / -78 °C / Inert atmosphere

With oxalyl dichloride; boron trifluoride diethyl etherate; dimethyl sulfoxide; In dichloromethane; toluene; 1.1: Swarts reaction;
DOI:10.1002/anie.201106762