diethyl 2-<1-(4-bromophenyl)-2-oxo-4-phenylazetidin-3-ylidene>propanedioate

Base Information

Chemical Name:diethyl 2-<1-(4-bromophenyl)-2-oxo-4-phenylazetidin-3-ylidene>propanedioate
CAS No.:122301-84-2
Molecular Formula:C₂₂H₂₀BrNO₅
Molecular Weight:458.308
Hs Code.:

Synonyms:diethyl 2-<1-(4-bromophenyl)-2-oxo-4-phenylazetidin-3-ylidene>propanedioate

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Chemical Property of diethyl 2-<1-(4-bromophenyl)-2-oxo-4-phenylazetidin-3-ylidene>propanedioate

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Technology Process of diethyl 2-<1-(4-bromophenyl)-2-oxo-4-phenylazetidin-3-ylidene>propanedioate

There total 2 articles about diethyl 2-<1-(4-bromophenyl)-2-oxo-4-phenylazetidin-3-ylidene>propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33912-40-2
1-(4-bromophenyl)-4-phenylazetidin-2-one

: 122301-84-2
diethyl 2-<1-(4-bromophenyl)-2-oxo-4-phenylazetidin-3-ylidene>propanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / 1.) LDA / tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) 5 min

2: 1.) LDA, chlorotrimethylsilane / 1.) THF, -78 deg C, 15 min; 15 min, 2.) -78 deg C to r.t.

With chloro-trimethyl-silane; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1002/ardp.19893220103

Reference yield:

: cis-1-(4-bromophenyl)-4-phenyl-3-(trimethylsilyl)azetidin-2-one

: 609-09-6
Diethyl ketomalonate

: 122301-84-2
diethyl 2-<1-(4-bromophenyl)-2-oxo-4-phenylazetidin-3-ylidene>propanedioate

Guidance literature:: With chloro-trimethyl-silane; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 15 min; 15 min, 2.) -78 deg C to r.t.;
DOI:10.1002/ardp.19893220103

Reference yield: 77.0%

: 122301-84-2
diethyl 2-<1-(4-bromophenyl)-2-oxo-4-phenylazetidin-3-ylidene>propanedioate

: diethyl trans-1-(4-bromophenyl)-2-oxo-4-phenylspiro-3',3'-dicarboxylate

Guidance literature:: With potassium hydroxide; dihydrogen peroxide; tetrabutylammomium bromide; In dichloromethane;
DOI:10.1002/hlca.19930760820