33912-40-2

Upstream product

• 105-36-2 ethyl bromoacetate 
• 780-20-1 N-benzylidene-4-bromoaniline 
• 5661-55-2 4-phenylazetidin-2-one 
• 5467-74-3 4-Bromophenylboronic acid 
• 316146-27-7 N-(4-bromophenyl)-3-phenylpropanamide 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 87342-67-4 (3S*,4R*)-1-(4-Bromphenyl)-3-<(S*)-(4-chlorphenyl)(hydroxy)methyl>-4-phenyl-2-azetidinon 
• 122301-70-6 Diethyl 1-(4-bromphenyl)-2-oxo-4-phenyl-3-<1-(4-bromphenyl)-3-trimethylsilyl-2-oxo-4-phenyl-3-azetidinyl>-3-azetidinylmalonat 
• 122301-84-2 diethyl 2-<1-(4-bromophenyl)-2-oxo-4-phenylazetidin-3-ylidene>propanedioate 
• 87342-66-3 (3S*,4R*)-1-(4-Bromphenyl)-3-<(S*)-(2-chlorphenyl)(hydroxy)methyl>-4-phenyl-2-azetidinon 

Relevant academic research and scientific papers

Copper-Catalyzed Oxidative Benzylic C(sp3)?H Cyclization for the Synthesis of β-Lactams

β-Lactams are important structural motifs because of their ubiquity in natural products and pharmaceuticals. We report herein a Cu-catalyzed intramolecular oxidative C(sp3)?H amidation for the synthesis of β-lactams using tBuOOtBu. This method

Bcl-2 INHIBITORS

Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.

Synthesis and Stereochemistry of 3-(α-Hydroxybenzyl)-1,4-diphenyl-2-azetidinones

Aldol reaction between benzaldehydes and 1,4-diphenyl-2-azetidinones 1 catalyzed by lithium diisopropylamide results in formation of the title compound The reactions give satisfactory yields and high diastereoselectivity at three centres in forming the αS