(S)-N-(1-amino-1-oxopropan-2-yl)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)picolinamide

Base Information

Chemical Name:(S)-N-(1-amino-1-oxopropan-2-yl)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)picolinamide
CAS No.:1355052-22-0
Molecular Formula:C₂₁H₁₇F₃N₄O₃
Molecular Weight:430.386
Hs Code.:

Synonyms:(S)-N-(1-amino-1-oxopropan-2-yl)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)picolinamide

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Chemical Property of (S)-N-(1-amino-1-oxopropan-2-yl)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)picolinamide

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Technology Process of (S)-N-(1-amino-1-oxopropan-2-yl)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)picolinamide

There total 5 articles about (S)-N-(1-amino-1-oxopropan-2-yl)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1355052-59-3
C₂₂H₁₈F₃N₃O₄

: 1355052-22-0
(S)-N-(1-amino-1-oxopropan-2-yl)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)picolinamide

Guidance literature:: With methanol; ammonia; for 18h;

Reference yield:

: 269409-70-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1355052-22-0
(S)-N-(1-amino-1-oxopropan-2-yl)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)picolinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 160 °C / Microwave irradiation

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 5 h / 80 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h

3.2: 20 h / 20 °C

4.1: ammonia; methanol / 18 h

With methanol; ammonia; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 69045-82-5
2-fluoro-5-(trifluoromethyl)pyridine

: 1355052-22-0
(S)-N-(1-amino-1-oxopropan-2-yl)-6-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)picolinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 160 °C / Microwave irradiation

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 5 h / 80 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h

3.2: 20 h / 20 °C

4.1: ammonia; methanol / 18 h

With methanol; ammonia; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;