N-Acetyl-N-[2-isopropyl-4-oxo-3(4H)-quinazolinyl]acetamide

Base Information

• Chemical Name: N-Acetyl-N-[2-isopropyl-4-oxo-3(4H)-quinazolinyl]acetamide
• CAS No.: 178244-37-6
• Molecular Formula: C15H17 N3 O3
• Molecular Weight: 287.31
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80350873
• Wikidata: Q82126962
• Mol file: 178244-37-6.mol

Synonyms:178244-37-6;N-Acetyl-N-[2-isopropyl-4-oxo-3(4H)-quinazolinyl]acetamide;N-acetyl-N-(4-oxo-2-propan-2-ylquinazolin-3-yl)acetamide;N-Acetyl-N-(2-isopropyl-4-oxoquinazolin-3(4H)-yl)acetamide;3-Diacetylamino-2-isopropylquinazolin-4-one;DTXSID80350873;AKOS025394466;J-011365;N-Acetyl-N-(2-isopropyl-4-oxo-3(4H)-quin-azolinyl)acetamide;N-acetyl-N-[4-oxo-2-(propan-2-yl)-3,4-dihydroquinazolin-3-yl]acetamide

Chemical Property of N-Acetyl-N-[2-isopropyl-4-oxo-3(4H)-quinazolinyl]acetamide

Chemical Property:

• Vapor Pressure: 1.6E-07mmHg at 25°C
• Melting Point: 87-98 °C(lit.)
• Refractive Index: 1.6
• Boiling Point: 427.7°C at 760 mmHg
• Flash Point: 212.5°C
• PSA: 72.27000
• Density: 1.23g/cm³
• LogP: 1.55090
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 287.12699141
• Heavy Atom Count: 21
• Complexity: 484

Purity/Quality:

99% ^*data from raw suppliers

N-ACETYL-N-[2-ISOPROPYL-4-OXO-3(4H)-QUINAZOLINYL]ACETAMIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)C1=NC2=CC=CC=C2C(=O)N1N(C(=O)C)C(=O)C

Technology Process of N-Acetyl-N-[2-isopropyl-4-oxo-3(4H)-quinazolinyl]acetamide

There total 2 articles about N-Acetyl-N-[2-isopropyl-4-oxo-3(4H)-quinazolinyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-acetylamino-2-isopropylquinazolin-4(3H)-one (144522-58-7) + acetyl chloride (75-36-5) → N-acetyl-N-(2-isopropyl-4-oxo-4H-quinazolin-3-yl)acetamide (178244-37-6)

Guidance literature:

With hydrazine; In neat (no solvent); for 0.0833333h; Reagent/catalyst; Solvent; Temperature; Time; Microwave irradiation; Green chemistry;

Reference yield: 81.0%

acetic anhydride (108-24-7) + 3-amino-2-isopropyl-3,4-dihydroquinazolin-4-one (70589-51-4) → N-acetyl-N-(2-isopropyl-4-oxo-4H-quinazolin-3-yl)acetamide (178244-37-6)

Guidance literature:

With pyridine;

DOI:10.1039/cc9960001051

Reference yield: 90.0%

N-acetyl-N-(2-isopropyl-4-oxo-4H-quinazolin-3-yl)acetamide (178244-37-6) → N1,N3-spermidinebis(acetamide) (82414-35-5) + 3-acetylamino-2-isopropylquinazolin-4(3H)-one (144522-58-7)

Guidance literature:

With N-(3-aminopropyl)-1,4-diaminobutane; In dichloromethane;

DOI:10.1039/cc9960001051

upstream raw materials:

acetic anhydride

3-amino-2-isopropyl-3,4-dihydroquinazolin-4-one

3-acetylamino-2-isopropylquinazolin-4(3H)-one

acetyl chloride

Downstream raw materials:

N-acetyl-4-hydroxypiperidine

acetamidoethyl piperazine

N¹,N³-spermidinebis(acetamide)

3-acetylamino-2-isopropylquinazolin-4(3H)-one