methyl N-benzyl-N-{3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-yl}aminoacetate

Base Information

• Chemical Name: methyl N-benzyl-N-{3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-yl}aminoacetate
• CAS No.: 1303995-60-9
• Molecular Formula: C₂₈H₃₆N₄O₅
• Molecular Weight: 508.618
• Mol file: 1303995-60-9.mol

Synonyms:methyl N-benzyl-N-{3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-yl}aminoacetate

Chemical Property of methyl N-benzyl-N-{3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-yl}aminoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-benzyl-N-{3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-yl}aminoacetate

There total 4 articles about methyl N-benzyl-N-{3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-yl}aminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-benzyl-3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-ylamine (1303995-59-6) + bromoacetic acid methyl ester (96-32-2) → methyl N-benzyl-N-{3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-yl}aminoacetate (1303995-60-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c0ob00887g

Reference yield:

C15H19N3O3 (1196894-77-5) → methyl N-benzyl-N-{3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-yl}aminoacetate (1303995-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With potassium carbonate; potassium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1039/c0ob00887g

Reference yield:

4-benzyloxy-2,6-bis(4,4-dimethyl-4,5-dihydrooxazol-2-yl)pyridine (1254959-93-7) → methyl N-benzyl-N-{3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-yl}aminoacetate (1303995-60-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

2.1: potassium hydroxide / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; potassium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1039/c0ob00887g

upstream raw materials:

C₁₅H₁₉N₃O₃

4-benzyloxy-2,6-bis(4,4-dimethyl-4,5-dihydrooxazol-2-yl)pyridine

4-(3-bromoprop-1-yloxy)-2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine

N-benzyl-3-[2,6-bis(4,4-dimethyloxazolin-2-yl)pyridine-4-yloxy]prop-1-ylamine