4-{6-[3-(4-tert-butyl-benzoylamino)-2-methyl-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzimidic acid ethyl ester hydrochloride

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Chemical Name:4-{6-[3-(4-tert-butyl-benzoylamino)-2-methyl-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzimidic acid ethyl ester hydrochloride
CAS No.:886855-47-6
Molecular Formula:C₃₃H₃₄N₆O₂*ClH
Molecular Weight:583.133
Hs Code.:

Synonyms:4-{6-[3-(4-tert-butyl-benzoylamino)-2-methyl-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzimidic acid ethyl ester hydrochloride

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Chemical Property of 4-{6-[3-(4-tert-butyl-benzoylamino)-2-methyl-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzimidic acid ethyl ester hydrochloride

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Technology Process of 4-{6-[3-(4-tert-butyl-benzoylamino)-2-methyl-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzimidic acid ethyl ester hydrochloride

There total 6 articles about 4-{6-[3-(4-tert-butyl-benzoylamino)-2-methyl-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzimidic acid ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886854-78-0
2-(2-methyl-3-nitrophenyl)-5,5-dimethyl[1,3,2]dioxaborinane

: 886855-47-6
4-{6-[3-(4-tert-butyl-benzoylamino)-2-methyl-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzimidic acid ethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h / 20 °C / 2068.65 Torr

2.1: 1,2-dimethoxyethane / 0.25 h / 20 °C

2.2: 0.17 h / 20 °C

2.3: 16 h / 95 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 20 °C

4.1: hydrogenchloride / 16 h / 0 - 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethyl acetate;

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 886855-47-6
4-{6-[3-(4-tert-butyl-benzoylamino)-2-methyl-phenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzimidic acid ethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h / 20 °C / 2068.65 Torr

3.1: 1,2-dimethoxyethane / 0.25 h / 20 °C

3.2: 0.17 h / 20 °C

3.3: 16 h / 95 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 20 °C

5.1: hydrogenchloride / 16 h / 0 - 20 °C

With hydrogenchloride; hydrogen; potassium acetate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethyl acetate;