N-[2-(2-Diethylamino-ethyl)-8-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid

Base Information

• Chemical Name: N-[2-(2-Diethylamino-ethyl)-8-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid
• CAS No.: 134330-58-8
• Molecular Formula: C₂₁H₁₉NO₂*C₄₀H₃₉N₅O₂S
• Molecular Weight: 971.235
• Mol file: 134330-58-8.mol

Synonyms:N-[2-(2-Diethylamino-ethyl)-8-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid

Chemical Property of N-[2-(2-Diethylamino-ethyl)-8-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(2-Diethylamino-ethyl)-8-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid

There total 3 articles about N-[2-(2-Diethylamino-ethyl)-8-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diethyl-8-methoxy-5-nitro-2H<1>benzothiopyrano<4,3,2-cd>indazole-2-ethanamine hydrochloride (114615-22-4) → N-[2-(2-Diethylamino-ethyl)-8-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid (134330-58-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / H₂, 5percent Pd-C / methanol; H₂O / 20.4 h / 25 °C / 2585.7 Torr

2: 1.) BBr₃ 2.) MeOH / 1.) CH₂Cl₂, 1,2-dichloroethane, reflux overnight 2.) 4h reflux

3: 1,1'-carbonyldiimidazole / 1.) DMF, 2h 2.) r. t., 18h

With methanol; palladium on activated charcoal; hydrogen; boron tribromide; 1,1'-carbonyldiimidazole; In methanol; water;

DOI:10.1002/jhet.5570280261

Reference yield:

5-amino-N,N-diethyl-8-methoxy-2H<1>benzothiopyrano<4,3,2-cd>indazole-2-ethanamine dihydrochloride (114615-33-7) → N-[2-(2-Diethylamino-ethyl)-8-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid (134330-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BBr₃ 2.) MeOH / 1.) CH₂Cl₂, 1,2-dichloroethane, reflux overnight 2.) 4h reflux

2: 1,1'-carbonyldiimidazole / 1.) DMF, 2h 2.) r. t., 18h

With methanol; boron tribromide; 1,1'-carbonyldiimidazole;

DOI:10.1002/jhet.5570280261

Reference yield:

Trt-Gly (5893-05-0) + 5-amino-N,N-diethyl-8-hydroxy-2H<1>benzothiopyrano<4,3,2-cd>indazole-2-ethanamine dihydrobromide (114615-32-6) → N-[2-(2-Diethylamino-ethyl)-8-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid (134330-58-8)

Guidance literature:

With 1,1'-carbonyldiimidazole; Yield given. Multistep reaction; 1.) DMF, 2h 2.) r. t., 18h;

DOI:10.1002/jhet.5570280261

upstream raw materials:

Trt-Gly

5-amino-N,N-diethyl-8-hydroxy-2H<1>benzothiopyrano<4,3,2-cd>indazole-2-ethanamine dihydrobromide

5-amino-N,N-diethyl-8-methoxy-2H<1>benzothiopyrano<4,3,2-cd>indazole-2-ethanamine dihydrochloride

N,N-diethyl-8-methoxy-5-nitro-2H<1>benzothiopyrano<4,3,2-cd>indazole-2-ethanamine hydrochloride

Downstream raw materials:

N-<2-<2-(diethylamino)ethyl>-8-hydroxy-2H<1>benzothiopyrano<4,3,2-cd>indazol-5-yl>-2-<(triphenylmethyl)amino>acetamide