trans-1,2-diphenyl-1-cyclopropanecarboxylic acid

Base Information

• Chemical Name: trans-1,2-diphenyl-1-cyclopropanecarboxylic acid
• CAS No.: 42333-02-8
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.286
• Mol file: 42333-02-8.mol

Synonyms:trans-1,2-diphenyl-1-cyclopropanecarboxylic acid

Chemical Property of trans-1,2-diphenyl-1-cyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-1,2-diphenyl-1-cyclopropanecarboxylic acid

There total 2 articles about trans-1,2-diphenyl-1-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1β,2β-diphenylcyclopropane-1α-carboxylate (120522-83-0,36634-63-6,36634-64-7,42332-99-0,42333-04-0,42333-06-2,42333-08-4,42333-10-8,42400-68-0) → (E)-1,2-diphenylcyclopropanecarboxylic acid (42333-01-7) + trans-1,2-diphenyl-1-cyclopropanecarboxylic acid (42333-02-8)

Guidance literature:

With sodium hydroxide; In ethanol; water; Ambient temperature;

DOI:10.1021/jo00171a025

Reference yield:

→ trans-1,2-diphenyl-1-cyclopropanecarboxylic acid (42333-02-8)

Guidance literature:

α-Phenylzimtsaeure, 1. Diazomethan, Trimethyloxosulfoniumiodid (-> Gemisch der diastereomeren Razemate von (1)), 2. alkal. Hydrolyse, 3. Isolierung von (Z)-Isomer ueber selektive Ausfaellung (unterschiedliche pK(a)-Werte);

DOI:10.1021/ja00794a019

Reference yield: 86.0%

N-hydroxyphthalimide (524-38-9) + trans-1,2-diphenyl-1-cyclopropanecarboxylic acid (42333-02-8) → cis-1,3-dioxoisoindolin-2-yl 1,2-diphenylcyclopropane-1-carboxylate

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1039/d1cc02930d

upstream raw materials:

methyl 1β,2β-diphenylcyclopropane-1α-carboxylate

Downstream raw materials:

2,4-diphenyl-γ-butyrolactone

(1S,2R)-1,2-Diphenyl-cyclopropanecarboxylic acid amide

(+)-(Z)-1-cyano-1,2-diphenylcyclopropane

(-)-(E)-1-cyano-1,2-diphenylcyclopropane