1-(4-chlorophenyl)-5-(2,6-difluoro-4-methoxyphenyl)-1,2-dihydro-2-methyl-3H-pyrazol-3-one

Base Information

Chemical Name:1-(4-chlorophenyl)-5-(2,6-difluoro-4-methoxyphenyl)-1,2-dihydro-2-methyl-3H-pyrazol-3-one
CAS No.:1293220-66-2
Molecular Formula:C₁₇H₁₃ClF₂N₂O₂
Molecular Weight:350.752
Hs Code.:

Synonyms:1-(4-chlorophenyl)-5-(2,6-difluoro-4-methoxyphenyl)-1,2-dihydro-2-methyl-3H-pyrazol-3-one

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Chemical Property of 1-(4-chlorophenyl)-5-(2,6-difluoro-4-methoxyphenyl)-1,2-dihydro-2-methyl-3H-pyrazol-3-one

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Technology Process of 1-(4-chlorophenyl)-5-(2,6-difluoro-4-methoxyphenyl)-1,2-dihydro-2-methyl-3H-pyrazol-3-one

There total 5 articles about 1-(4-chlorophenyl)-5-(2,6-difluoro-4-methoxyphenyl)-1,2-dihydro-2-methyl-3H-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1293220-95-7
ethyl 2,6-difluoro-4-methoxy-β-oxobenzenepropanoate

: 1-(4-chlorophenyl)-2-methylhydrazine

: 1293220-66-2
1-(4-chlorophenyl)-5-(2,6-difluoro-4-methoxyphenyl)-1,2-dihydro-2-methyl-3H-pyrazol-3-one

Guidance literature:: ethyl 2,6-difluoro-4-methoxy-β-oxobenzenepropanoate; 1-(4-chlorophenyl)-2-methylhydrazine; With pyridine; at 90 ℃; for 12h;

With toluene-4-sulfonic acid; In toluene; at 140 ℃; for 1h; Microwave irradiation;

Reference yield:

: 123843-65-2
2,6-difluoro-4-methoxybenzoic acid

: 1293220-66-2
1-(4-chlorophenyl)-5-(2,6-difluoro-4-methoxyphenyl)-1,2-dihydro-2-methyl-3H-pyrazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 50 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / -78 - -40 °C

2.2: -78 - 20 °C

3.1: pyridine / 12 h / 90 °C

3.2: 1 h / 140 °C / Microwave irradiation

With pyridine; n-butyllithium; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; hexanes; dichloromethane;

Reference yield:

: 125369-56-4
2,6-difluoro-4-methoxybenzoyl chloride

: 1293220-66-2
1-(4-chlorophenyl)-5-(2,6-difluoro-4-methoxyphenyl)-1,2-dihydro-2-methyl-3H-pyrazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / -78 - -40 °C

1.2: -78 - 20 °C

2.1: pyridine / 12 h / 90 °C

2.2: 1 h / 140 °C / Microwave irradiation

With pyridine; n-butyllithium; In tetrahydrofuran; hexanes;