(3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[3-hydroxy-3'-(methylthio)biphenyl-4-yl]-1-phenylazetidin-2-one

Base Information

Chemical Name:(3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[3-hydroxy-3'-(methylthio)biphenyl-4-yl]-1-phenylazetidin-2-one
CAS No.:852204-37-6
Molecular Formula:C₃₁H₂₈FNO₃S
Molecular Weight:513.633
Hs Code.:

Synonyms:(3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[3-hydroxy-3'-(methylthio)biphenyl-4-yl]-1-phenylazetidin-2-one

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Chemical Property of (3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[3-hydroxy-3'-(methylthio)biphenyl-4-yl]-1-phenylazetidin-2-one

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Technology Process of (3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[3-hydroxy-3'-(methylthio)biphenyl-4-yl]-1-phenylazetidin-2-one

There total 2 articles about (3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[3-hydroxy-3'-(methylthio)biphenyl-4-yl]-1-phenylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852204-36-5
5-bromo-2-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}phenyl acetate

: 128312-11-8
3-methylthiophenylboronic acid

: 852204-37-6
(3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[3-hydroxy-3'-(methylthio)biphenyl-4-yl]-1-phenylazetidin-2-one

: 852204-38-7
4-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-(methylthio)biphenyl-3-yl acetate

Guidance literature:: 5-bromo-2-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}phenyl acetate; 3-methylthiophenylboronic acid; With water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 60 ℃; for 4h;

With hydrogenchloride; In ethanol; water; toluene;

Reference yield:

: 852204-22-9
5-bromo-2-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}phenyl acetate

: 852204-37-6
(3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[3-hydroxy-3'-(methylthio)biphenyl-4-yl]-1-phenylazetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen fluoride / acetonitrile / 4 h / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 4 h / 60 °C

With hydrogen fluoride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; acetonitrile;

Reference yield:

: 852204-37-6
(3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[3-hydroxy-3'-(methylthio)biphenyl-4-yl]-1-phenylazetidin-2-one

: 852204-38-7
4-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-(methylthio)biphenyl-3-yl acetate

: C₃₁H₂₈FNO₅S

Guidance literature:: (3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[3-hydroxy-3'-(methylthio)biphenyl-4-yl]-1-phenylazetidin-2-one; 4-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-(methylthio)biphenyl-3-yl acetate; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃;

With trifluoroacetic anhydride; In dichloromethane; at 20 ℃; for 4h;

With methanol; water; triethylamine; 3-chloro-benzenecarboperoxoic acid; more than 3 stages;