2-amino-N-methyl-N-[3-[(2,4-dimethoxy)pyrimidine-5-yl]prop-2-ynyl]benzamide

Base Information

Chemical Name:2-amino-N-methyl-N-[3-[(2,4-dimethoxy)pyrimidine-5-yl]prop-2-ynyl]benzamide
CAS No.:1350705-14-4
Molecular Formula:C₁₇H₁₈N₄O₃
Molecular Weight:326.355
Hs Code.:

Synonyms:2-amino-N-methyl-N-[3-[(2,4-dimethoxy)pyrimidine-5-yl]prop-2-ynyl]benzamide

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Chemical Property of 2-amino-N-methyl-N-[3-[(2,4-dimethoxy)pyrimidine-5-yl]prop-2-ynyl]benzamide

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Technology Process of 2-amino-N-methyl-N-[3-[(2,4-dimethoxy)pyrimidine-5-yl]prop-2-ynyl]benzamide

There total 2 articles about 2-amino-N-methyl-N-[3-[(2,4-dimethoxy)pyrimidine-5-yl]prop-2-ynyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2-amino-N-methyl-N-(prop-2-yn-1-yl)benzamide

: 52522-99-3
2,4-dimethoxy-5-iodopyrimidine

: 1350705-14-4
2-amino-N-methyl-N-[3-[(2,4-dimethoxy)pyrimidine-5-yl]prop-2-ynyl]benzamide

Guidance literature:: 2,4-dimethoxy-5-iodopyrimidine; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

2-amino-N-methyl-N-(prop-2-yn-1-yl)benzamide; With copper(l) iodide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c1ob06353g

Reference yield:

: 118-48-9
isatoic anhydride

: 1350705-14-4
2-amino-N-methyl-N-[3-[(2,4-dimethoxy)pyrimidine-5-yl]prop-2-ynyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-dioxane / 3 h / 100 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1039/c1ob06353g

Reference yield:

: 1350705-14-4
2-amino-N-methyl-N-[3-[(2,4-dimethoxy)pyrimidine-5-yl]prop-2-ynyl]benzamide

: 609-15-4
ethyl 2-chloro-3-oxo-butyrate

: C₂₁H₂₂ClN₅O₅

Guidance literature:: 2-amino-N-methyl-N-[3-[(2,4-dimethoxy)pyrimidine-5-yl]prop-2-ynyl]benzamide; With hydrogenchloride; sodium nitrite; In water; at 0 - 3 ℃; for 1.25h;

ethyl 2-chloro-3-oxo-butyrate; In water; at 0 - 20 ℃; for 5h;
DOI:10.1039/c1ob06353g