phosphoric acid di-tert-butyl ester 4-[4-[(2,6-dichloro-benzoylamino)-methyl]-phenyl]-2-oxo-2H-pyridin-1-ylmethyl ester

Base Information

Chemical Name:phosphoric acid di-tert-butyl ester 4-[4-[(2,6-dichloro-benzoylamino)-methyl]-phenyl]-2-oxo-2H-pyridin-1-ylmethyl ester
CAS No.:1416975-56-8
Molecular Formula:C₂₈H₃₃Cl₂N₂O₆P
Molecular Weight:595.46
Hs Code.:

Synonyms:phosphoric acid di-tert-butyl ester 4-[4-[(2,6-dichloro-benzoylamino)-methyl]-phenyl]-2-oxo-2H-pyridin-1-ylmethyl ester

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Chemical Property of phosphoric acid di-tert-butyl ester 4-[4-[(2,6-dichloro-benzoylamino)-methyl]-phenyl]-2-oxo-2H-pyridin-1-ylmethyl ester

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Technology Process of phosphoric acid di-tert-butyl ester 4-[4-[(2,6-dichloro-benzoylamino)-methyl]-phenyl]-2-oxo-2H-pyridin-1-ylmethyl ester

There total 7 articles about phosphoric acid di-tert-butyl ester 4-[4-[(2,6-dichloro-benzoylamino)-methyl]-phenyl]-2-oxo-2H-pyridin-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416975-55-7
2,6-dichloro-N-[4-(1-chloromethyl-2-oxo-1,2-dihydro-pyridin-4-yl)-benzyl]-benzamide

: 33494-80-3
potassium di-tert-butylphosphate

: 1416975-56-8
phosphoric acid di-tert-butyl ester 4-[4-[(2,6-dichloro-benzoylamino)-methyl]-phenyl]-2-oxo-2H-pyridin-1-ylmethyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

Reference yield:

: 4659-45-4
2,6-Dichlorobenzoyl chloride

: 1416975-56-8
phosphoric acid di-tert-butyl ester 4-[4-[(2,6-dichloro-benzoylamino)-methyl]-phenyl]-2-oxo-2H-pyridin-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / 20 °C

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 70 °C / Inert atmosphere

3: formic acid / dichloromethane / 3 h / 40 °C

4: dichloromethane; N,N-dimethyl-formamide / 5 h / 20 °C

5: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C

With formic acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1416975-48-8
4-[(2,6-dichloro-benzoylamino)methyl]phenylboronic acid

: 1416975-56-8
phosphoric acid di-tert-butyl ester 4-[4-[(2,6-dichloro-benzoylamino)-methyl]-phenyl]-2-oxo-2H-pyridin-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 70 °C / Inert atmosphere

2: formic acid / dichloromethane / 3 h / 40 °C

3: dichloromethane; N,N-dimethyl-formamide / 5 h / 20 °C

4: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C

With formic acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water; N,N-dimethyl-formamide;