tert-Butoxycarbonylamino-acetic acid (3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methylene-tetrahydro-pyran-3-yl ester

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Chemical Name:tert-Butoxycarbonylamino-acetic acid (3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methylene-tetrahydro-pyran-3-yl ester
CAS No.:240415-64-9
Molecular Formula:C₃₅H₄₁NO₈
Molecular Weight:603.712
Hs Code.:

Synonyms:tert-Butoxycarbonylamino-acetic acid (3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methylene-tetrahydro-pyran-3-yl ester

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Chemical Property of tert-Butoxycarbonylamino-acetic acid (3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methylene-tetrahydro-pyran-3-yl ester

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Technology Process of tert-Butoxycarbonylamino-acetic acid (3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methylene-tetrahydro-pyran-3-yl ester

There total 3 articles about tert-Butoxycarbonylamino-acetic acid (3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methylene-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 4530-20-5
BOC-glycine

: 240415-45-6
(3R,4R,5S,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-methylene-tetrahydro-pyran-3-ol

: 240415-64-9
tert-Butoxycarbonylamino-acetic acid (3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methylene-tetrahydro-pyran-3-yl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/S0040-4039(99)01055-2

Reference yield:

: 20672-66-6,40246-26-2,84926-76-1,114179-79-2,115184-49-1
3,4,5-tri-O-benzyl-D-galactopyranose

: 240415-64-9
tert-Butoxycarbonylamino-acetic acid (3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methylene-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / n-BuLi / tetrahydrofuran

2: 86 percent

3: 92 percent / DCC; DMAP / CH₂Cl₂

With dmap; n-butyllithium; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; 1: Wittig olefination / 3: Esterification;
DOI:10.1016/S0040-4039(99)01055-2

Reference yield:

: 115649-78-0
1,2-dideoxy-4,5,7-tri-O-benzyl-D-galacto-1-heptenitol

: 240415-64-9
tert-Butoxycarbonylamino-acetic acid (3R,4S,5S,6R)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methylene-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent

2: 92 percent / DCC; DMAP / CH₂Cl₂

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; 2: Esterification;
DOI:10.1016/S0040-4039(99)01055-2