N-Deshydroxyethyl Dasatinib

Base Information

• Chemical Name: N-Deshydroxyethyl Dasatinib
• CAS No.: 910297-51-7
• Molecular Formula: C₂₀H₂₂ClN₇OS
• Molecular Weight: 443.96
• Mol file: 910297-51-7.mol

Synonyms:N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide

Chemical Property of N-Deshydroxyethyl Dasatinib

Chemical Property:

• Melting Point: >300°C
• PKA: 10.94±0.70(Predicted)
• Density: 1.403±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99%+, ^*data from raw suppliers

N-Deshydroxyethyl Dasatinib ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Deshydroxyethyl Dasatinib is a metabolite of Dasatinib, Used in the treatment of cancers and immune diseases. A metabolite of Dasatinib. Used in the treatment of cancers and immune diseases. It is a COVID19-related research product.

Technology Process of N-Deshydroxyethyl Dasatinib

There total 13 articles about N-Deshydroxyethyl Dasatinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

piperazine (110-85-0) + 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (302964-08-5) → N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide (910297-51-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 100 ℃; for 4h;

DOI:10.1039/c8md00412a

Reference yield: 98.0%

C24H27Cl2N7O3S → N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide (910297-51-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 8h;

Reference yield: 93.5%

tbutyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazine-1-carboxylate → N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide (910297-51-7)

Guidance literature:

With hydrogenchloride; In water; at 55 - 60 ℃; for 3h;

DOI:10.1080/00397911.2017.1337150

upstream raw materials:

piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide

2,4-dichloro-2-methylpyrimidine

Downstream raw materials:

ethyl 2-(4-(6-(5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-ylamino)-2-methylpyrimidin-4-yl)piperazin-1-yl)acetate

Refernces

• 1、 -. "PROTEIN DEGRADATION TARGETING COMPOUND, ANTI-TUMOR APPLICATION, INTERMEDIATE THEREOF AND USE OF INTERMEDIATE". Paragraph 0382-0383. . Retrieved 2021/02/18.
• 2、 -. "BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE". Page/Page column 334. . Retrieved 2021/04/01.