(2R,3R,6S,8S,9R,11R,1R)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-<1-methyl-2-oxo-(1H-pyrrol-2-yl)ethyl>-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane

Base Information

Chemical Name:(2R,3R,6S,8S,9R,11R,1R)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-<1-methyl-2-oxo-(1H-pyrrol-2-yl)ethyl>-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane
CAS No.:95015-24-0
Molecular Formula:C₃₇H₅₁NO₄Si
Molecular Weight:601.902
Hs Code.:

Synonyms:(2R,3R,6S,8S,9R,11R,1R)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-<1-methyl-2-oxo-(1H-pyrrol-2-yl)ethyl>-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane

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Chemical Property of (2R,3R,6S,8S,9R,11R,1R)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-<1-methyl-2-oxo-(1H-pyrrol-2-yl)ethyl>-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane

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Technology Process of (2R,3R,6S,8S,9R,11R,1R)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-<1-methyl-2-oxo-(1H-pyrrol-2-yl)ethyl>-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane

There total 16 articles about (2R,3R,6S,8S,9R,11R,1R)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-<1-methyl-2-oxo-(1H-pyrrol-2-yl)ethyl>-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 5362-33-4
Pyrrol-2-ylmagnesium bromide

: 95015-23-9
<2R,3R,6S,8S,9R,11R,1''R>-2-(2'-t-butyldiphenylsilyloxyethyl)-8-<1''-methyl-2''-oxo-2''-(pyrid-2-ylthio)ethyl>-1,7-dioxaspiro<5,5>undecane

: 95015-24-0
(2R,3R,6S,8S,9R,11R,1R)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-<1-methyl-2-oxo-(1H-pyrrol-2-yl)ethyl>-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane

Guidance literature:: With copper(l) iodide; In tetrahydrofuran; diethyl ether; at 0 - 5 ℃; for 1h;
DOI:10.1016/S0040-4020(01)88109-6

Reference yield:

: 95015-22-8
(2R,3R,6S,8S,9R,11R,1R)-(+)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-(2-hydroxy-1-methylethyl)-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane

: 95015-24-0
(2R,3R,6S,8S,9R,11R,1R)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-<1-methyl-2-oxo-(1H-pyrrol-2-yl)ethyl>-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane

Guidance literature:: Multi-step reaction with 3 steps

1: Jones' reagent / acetone / 0.33 h

2: triphenylphosphine / CH₂Cl₂ / 3 h / Ambient temperature

3: 80 percent / CuI / tetrahydrofuran; diethyl ether / 1 h / 0 - 5 °C

With copper(l) iodide; jones' reagent; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)88109-6

Reference yield:

: 100845-52-1
(2R,3R,6S,8S,9R,11R,1R)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-(1-methyl-2-carboxyethyl)-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane

: 95015-24-0
(2R,3R,6S,8S,9R,11R,1R)-2-<<(2'-tert-butyldiphenylsilyl)oxy>ethyl>-8-<1-methyl-2-oxo-(1H-pyrrol-2-yl)ethyl>-3,9,11-trimethyl-1,7-dioxaspiro<5.5>undecane

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine / CH₂Cl₂ / 3 h / Ambient temperature

2: 80 percent / CuI / tetrahydrofuran; diethyl ether / 1 h / 0 - 5 °C

With copper(l) iodide; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(01)88109-6