N-benzyloxycarbonyl-4-methoxycarbonyl-L-phenylalanine

Base Information

Chemical Name:N-benzyloxycarbonyl-4-methoxycarbonyl-L-phenylalanine
CAS No.:169158-08-1
Molecular Formula:C₁₉H₁₉NO₆
Molecular Weight:357.363
Hs Code.:
DSSTox Substance ID:DTXSID301174409
Nikkaji Number:J276.771F

Synonyms:SCHEMBL7305160;BGLGUVWKEAGEEO-INIZCTEOSA-N;DTXSID301174409;N-benzyloxycarbonyl-4-methoxycarbonyl-L-phenylalanine;N-(Benzyloxycarbonyl)-4-(methoxycarbonyl)-L-phenylalanine;4-(Methoxycarbonyl)-N-[(phenylmethoxy)carbonyl]-L-phenylalanine;169158-08-1

Suppliers and Price of N-benzyloxycarbonyl-4-methoxycarbonyl-L-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyloxycarbonyl-4-methoxycarbonyl-L-phenylalanine

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:357.12123733
Heavy Atom Count:26
Complexity:480

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=CC=C(C=C1)CC(C(=O)O)NC(=O)OCC2=CC=CC=C2
Isomeric SMILES:COC(=O)C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)OCC2=CC=CC=C2

Technology Process of N-benzyloxycarbonyl-4-methoxycarbonyl-L-phenylalanine

There total 4 articles about N-benzyloxycarbonyl-4-methoxycarbonyl-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 169158-07-0
methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-(tert-butoxy)-3-oxopropyl]benzoate

: 169158-08-1
(2S)-2-[(benzyloxycarbonyl)amino]-3-[4-(methoxycarbonyl)phenyl]propanoic acid

Guidance literature:: With trifluoroacetic acid; In toluene; at 20 ℃; for 1h;
DOI:10.1248/cpb.49.258

Reference yield:

: 145205-85-2
(S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)-phenyl)propanoate

: 169158-08-1
(2S)-2-[(benzyloxycarbonyl)amino]-3-[4-(methoxycarbonyl)phenyl]propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; Et₃N / dimethylsulfoxide / 2 h / 80 °C

2: 99 percent / CF₃COOH / toluene / 1 h / 20 °C

With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; trifluoroacetic acid; In dimethyl sulfoxide; toluene;
DOI:10.1248/cpb.49.258

Reference yield:

: 16881-33-7
(S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoate hydrate

: 169158-08-1
(2S)-2-[(benzyloxycarbonyl)amino]-3-[4-(methoxycarbonyl)phenyl]propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / 2,6-lutidine; 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / 20 °C

2: 93 percent / Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; Et₃N / dimethylsulfoxide / 2 h / 80 °C

3: 99 percent / CF₃COOH / toluene / 1 h / 20 °C

With 2,6-dimethylpyridine; dmap; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1248/cpb.49.258