methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoate

Base Information

Chemical Name:methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoate
CAS No.:169158-09-2
Molecular Formula:C₃₂H₃₉N₃O₁₀
Molecular Weight:625.676
Hs Code.:

Synonyms:methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoate

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Chemical Property of methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoate

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Technology Process of methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoate

There total 4 articles about methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 169158-08-1
(2S)-2-[(benzyloxycarbonyl)amino]-3-[4-(methoxycarbonyl)phenyl]propanoic acid

: 169157-67-9
(S)-3-methoxycarbonylmethyl-2-oxopiperazine-1-acetic acid tert-butyl ester

: 169158-09-2
methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1248/cpb.49.258

Reference yield:

: 169158-07-0
methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-(tert-butoxy)-3-oxopropyl]benzoate

: 169158-09-2
methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / CF₃COOH / toluene / 1 h / 20 °C

2: 51 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 2 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1248/cpb.49.258

Reference yield:

: 145205-85-2
(S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)-phenyl)propanoate

: 169158-09-2
methyl 4-[(2S)-2-[(benzyloxycarbonyl)amino]-3-[(2S)-4-[2-(tert-butoxy)-2-oxoethyl]-2-(2-methoxy-2-oxoethyl)-3-oxopiperazinyl]-3-oxopropyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; Et₃N / dimethylsulfoxide / 2 h / 80 °C

2: 99 percent / CF₃COOH / toluene / 1 h / 20 °C

3: 51 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 2 h / 20 °C

With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1248/cpb.49.258