2-(2-[1,3]dioxan-2-ylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:2-(2-[1,3]dioxan-2-ylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester
CAS No.:1181669-50-0
Molecular Formula:C₁₇H₂₀O₆
Molecular Weight:320.342
Hs Code.:

Synonyms:2-(2-[1,3]dioxan-2-ylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

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Chemical Property of 2-(2-[1,3]dioxan-2-ylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

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Technology Process of 2-(2-[1,3]dioxan-2-ylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

There total 3 articles about 2-(2-[1,3]dioxan-2-ylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1181669-48-6
2-(2-[1,3]dioxan-2-ylbenzylidene)malonic acid dimethyl ester

: 1774-47-6
trimethylsulfoxonium iodide

: 1181669-50-0
2-(2-[1,3]dioxan-2-ylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; mineral oil; Inert atmosphere;

2-(2-[1,3]dioxan-2-ylbenzylidene)malonic acid dimethyl ester; In dimethyl sulfoxide; mineral oil; for 19h; Inert atmosphere;
DOI:10.1021/ol901454y

Reference yield:

: 139086-86-5
2-(1,3-dioxan-2-yl)benzaldehyde

: 1181669-50-0
2-(2-[1,3]dioxan-2-ylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: L-proline / dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / Inert atmosphere

2.2: 19 h / Inert atmosphere

With sodium hydride; L-proline; In dimethyl sulfoxide; mineral oil;
DOI:10.1021/ol901454y

Reference yield:

: 643-79-8
o-phthalic dicarboxaldehyde

: 1181669-50-0
2-(2-[1,3]dioxan-2-ylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 20 h / Inert atmosphere; Reflux

2.1: L-proline / dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere

3.1: sodium hydride / dimethyl sulfoxide; mineral oil / Inert atmosphere

3.2: 19 h / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; L-proline; In dimethyl sulfoxide; toluene; mineral oil;
DOI:10.1021/ol901454y