1181669-48-6

Basic information

• Product Name: 2-(2-[1,3]dioxan-2-ylbenzylidene)malonic acid dimethyl ester
• Synonyms: 2-(2-[1,3]dioxan-2-ylbenzylidene)malonic acid dimethyl ester
• CAS NO: 1181669-48-6
• Molecular Weight: 306.315
• Mol File: 1181669-48-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-[1,3]dioxan-2-ylbenzylidene)malonic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-[1,3]dioxan-2-ylbenzylidene)malonic acid dimethyl ester(1181669-48-6)
• EPA Substance Registry System: 2-(2-[1,3]dioxan-2-ylbenzylidene)malonic acid dimethyl ester(1181669-48-6)

Safety Data

• Hazardous Substances Data: 1181669-48-6(Hazardous Substances Data)

Upstream product

• 643-79-8 o-phthalic dicarboxaldehyde 
• 139086-86-5 2-(1,3-dioxan-2-yl)benzaldehyde 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 1181669-45-3 2-(2-formylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester 
• 1181669-50-0 2-(2-[1,3]dioxan-2-ylphenyl)cyclopropane-1,1-dicarboxylic acid dimethyl ester 

Relevant articles and documents

Domino synthesis of bridged bicyclic tetrahydro-1,2-oxazines: Access to stereodefined 4-aminocyclohexanols

Image Presented The intramolecular variant of the homo-[3 + 2]-dipolar cycloaddition of nitrones (generated in situ from an aldehyde and a hydroxylamine) with donor-acceptor cyclopropanes allows for the efficient synthesis of bridged tetrahydro-1,2-oxazines. This domino sequence produces adducts amenable to reductive N-O bond cleavage producing cis-1,4- aminocyclohexanols in excellent yields.