(2E)-3-[4-([(2-hydroxyethyl)-[2-(1H-indol-3-yl)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

Base Information

Chemical Name:(2E)-3-[4-([(2-hydroxyethyl)-[2-(1H-indol-3-yl)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester
CAS No.:619324-72-0
Molecular Formula:C₂₃H₂₆N₂O₃
Molecular Weight:378.471
Hs Code.:

Synonyms:(2E)-3-[4-([(2-hydroxyethyl)-[2-(1H-indol-3-yl)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

Suppliers and Price of (2E)-3-[4-([(2-hydroxyethyl)-[2-(1H-indol-3-yl)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2E)-3-[4-([(2-hydroxyethyl)-[2-(1H-indol-3-yl)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

Chemical Property:

Purity/Quality:: HPLC≥98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (2E)-3-[4-([(2-hydroxyethyl)-[2-(1H-indol-3-yl)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

There total 3 articles about (2E)-3-[4-([(2-hydroxyethyl)-[2-(1H-indol-3-yl)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 540-51-2
2-bromoethanol

: 404951-55-9
(2E)-3-[4-[[[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenoic acid methyl ester

: 619324-72-0
(2E)-3-[4-([(2-hydroxyethyl)-[2-(1H-indol-3-yl)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 ℃; for 18h;
DOI:10.1021/jm030235w

Reference yield:

: 61-54-1
tryptamine

: 619324-72-0
(2E)-3-[4-([(2-hydroxyethyl)-[2-(1H-indol-3-yl)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane

2: 62 percent / K₂CO₃ / acetonitrile / 18 h / 60 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm030235w

Reference yield:

: 7560-50-1,71093-79-3,58045-41-3
methyl (2E)-3-(4-formylphenyl)acrylate

: 619324-72-0
(2E)-3-[4-([(2-hydroxyethyl)-[2-(1H-indol-3-yl)ethyl]amino]methyl)phenyl]-2-propenoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane

2: 62 percent / K₂CO₃ / acetonitrile / 18 h / 60 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm030235w