1-[(2-hydroxynaphthalen-1-yl)[4-[2-(piperidin-1-yl)ethoxy]phenyl]methyl]piperidin-4-ol

Base Information

Chemical Name:1-[(2-hydroxynaphthalen-1-yl)[4-[2-(piperidin-1-yl)ethoxy]phenyl]methyl]piperidin-4-ol
CAS No.:1335047-77-2
Molecular Formula:C₂₉H₃₆N₂O₃
Molecular Weight:460.616
Hs Code.:

Synonyms:1-[(2-hydroxynaphthalen-1-yl)[4-[2-(piperidin-1-yl)ethoxy]phenyl]methyl]piperidin-4-ol

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Chemical Property of 1-[(2-hydroxynaphthalen-1-yl)[4-[2-(piperidin-1-yl)ethoxy]phenyl]methyl]piperidin-4-ol

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Technology Process of 1-[(2-hydroxynaphthalen-1-yl)[4-[2-(piperidin-1-yl)ethoxy]phenyl]methyl]piperidin-4-ol

There total 3 articles about 1-[(2-hydroxynaphthalen-1-yl)[4-[2-(piperidin-1-yl)ethoxy]phenyl]methyl]piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 26815-04-3
4-(2-(piperidin-1-yl)ethoxy)benzaldehyde

: 135-19-3
β-naphthol

: 1335047-77-2
1-[(2-hydroxynaphthalen-1-yl)[4-[2-(piperidin-1-yl)ethoxy]phenyl]methyl]piperidin-4-ol

Guidance literature:: With toluene-4-sulfonic acid; at 125 ℃; Microwave irradiation; Neat (no solvent);
DOI:10.1016/j.ejmech.2011.05.054

Reference yield:

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 1335047-77-2
1-[(2-hydroxynaphthalen-1-yl)[4-[2-(piperidin-1-yl)ethoxy]phenyl]methyl]piperidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 2 h / Inert atmosphere; Reflux

1.2: Inert atmosphere; Reflux

2.1: toluene-4-sulfonic acid / 125 °C / Microwave irradiation; Neat (no solvent)

With potassium carbonate; toluene-4-sulfonic acid; In acetone; 2.1: Mannich reaction;
DOI:10.1016/j.ejmech.2011.05.054

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1335047-77-2
1-[(2-hydroxynaphthalen-1-yl)[4-[2-(piperidin-1-yl)ethoxy]phenyl]methyl]piperidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 2 h / Inert atmosphere; Reflux

1.2: Inert atmosphere; Reflux

2.1: toluene-4-sulfonic acid / 125 °C / Microwave irradiation; Neat (no solvent)

With potassium carbonate; toluene-4-sulfonic acid; In acetone; 2.1: Mannich reaction;
DOI:10.1016/j.ejmech.2011.05.054